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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
2000-1-24
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|
pubmed:abstractText |
6-(1-azidoalkyl)-DMNQ derivatives compared to 2-(1-azidoalkyl)-DMNQ isomers, exhibited higher cytotoxic activity against L1210 mouse leukemia cells and stronger inhibition of DNA topoisomerase-I (TOPO-I), suggesting involvement of steric hindrance. However, similar antitumor activity against mice bearing S-180 cell was shown by 2- and 6-(1-azidoalkyl)-DMNQ derivatives.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0253-6269
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
22
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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|
pubmed:pagination |
507-14
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|
pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10549580-Animals,
pubmed-meshheading:10549580-Antineoplastic Agents,
pubmed-meshheading:10549580-Azides,
pubmed-meshheading:10549580-Chromatography, Thin Layer,
pubmed-meshheading:10549580-Drug Screening Assays, Antitumor,
pubmed-meshheading:10549580-Enzyme Inhibitors,
pubmed-meshheading:10549580-Leukemia L1210,
pubmed-meshheading:10549580-Male,
pubmed-meshheading:10549580-Mice,
pubmed-meshheading:10549580-Mice, Inbred ICR,
pubmed-meshheading:10549580-Naphthoquinones,
pubmed-meshheading:10549580-Neoplasm Transplantation,
pubmed-meshheading:10549580-Sarcoma, Experimental,
pubmed-meshheading:10549580-Structure-Activity Relationship,
pubmed-meshheading:10549580-Topoisomerase I Inhibitors,
pubmed-meshheading:10549580-Tumor Cells, Cultured
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pubmed:year |
1999
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|
pubmed:articleTitle |
2- or 6-(1-azidoalkyl)-5,8-dimethoxy-1,4-naphthoquinone: synthesis, evaluation of cytotoxic activity, antitumor activity and inhibitory effect on DNA topoisomerase-I.
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pubmed:affiliation |
College of Pharmacy, Chungnam National University, Taejon, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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