|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1999-11-24
|
|
pubmed:abstractText |
The contraceptive efficacy and safety of a progesterone-releasing vaginal ring (PVR) manufactured in Chile were compared to that of the Copper T 380A IUD (T-Cu) in nursing women enrolled at three Chilean clinics. A total of 285 volunteers chose to use the PVR and 262 the T-Cu. Plasma progesterone levels attained with the ring decreased from 25 to 14 nmol/L from month 1 to month 3 of use. Ring replacement was scheduled every 3 months. Volunteers continued in the study until weaning or completing the continuous use of four PVRs. No pregnancies occurred in 2320 and 2183 woman-months of exposure with the PVR and the T-Cu, respectively. Lower continuation rates in the first 6 months because of problems with use and a longer lactational amenorrhea were observed in the PVR than in the T-Cu group. Breast-feeding performance and infant growth were similar in both groups. These results confirm the high efficacy and safety of the PVR for nursing women and have led to the registration of the PVR by Chilean health authorities.
|
|
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Americas,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Chile,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Progestin,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Effectiveness,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Iud,
http://linkedlifedata.com/resource/pubmed/keyword/Iud, Copper Releasing,
http://linkedlifedata.com/resource/pubmed/keyword/Latin America,
http://linkedlifedata.com/resource/pubmed/keyword/PROGESTERONE,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Progestational Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/South America,
http://linkedlifedata.com/resource/pubmed/keyword/Vaginal Rings
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0010-7824
|
|
pubmed:author |
pubmed-author:BravoCC,
pubmed-author:CasadoM EME,
pubmed-author:ChandíaOO,
pubmed-author:CroxattoH BHB,
pubmed-author:DíazSS,
pubmed-author:FetisGG,
pubmed-author:LavínPP,
pubmed-author:MassaiRR,
pubmed-author:MirandaPP,
pubmed-author:PeraltaOO,
pubmed-author:SilvaM AMA,
pubmed-author:ValdésPP,
pubmed-author:ZepedaAA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
9-14
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:otherAbstract |
PIP: This study compares the contraceptive efficacy and safety of a progesterone-releasing vaginal ring (PVR) manufactured in Chile and a Copper T 380A IUD (T-Cu) in nursing women enrolled at three Chilean clinics. A total of 285 volunteers used the PVR and 262 used T-Cu. Plasma progesterone levels attained with the ring decreased from 25 to 14 nmol/l from month 1 to month 3 of use. Ring replacement was scheduled every 3 months. Volunteers continued in the study until weaning or completing the continuous use of 4 PVRs. There were no pregnancies in 2320 and 2183 woman-months of exposure with the PVR and the T-Cu, respectively. Lower continuation rates in the first 6 months because of problems with use and a longer lactational amenorrhea were seen in the PVR group. Breast-feeding performance and infant growth were similar in both groups. These results prove the high efficacy and safety of the PVR for nursing women. This has led to the registration of the PVR by Chilean health authorities.
|
|
pubmed:meshHeading |
pubmed-meshheading:10549447-Adult,
pubmed-meshheading:10549447-Amenorrhea,
pubmed-meshheading:10549447-Birth Weight,
pubmed-meshheading:10549447-Body Weight,
pubmed-meshheading:10549447-Breast Feeding,
pubmed-meshheading:10549447-Chile,
pubmed-meshheading:10549447-Colposcopy,
pubmed-meshheading:10549447-Contraceptive Devices, Female,
pubmed-meshheading:10549447-Female,
pubmed-meshheading:10549447-Hemoglobins,
pubmed-meshheading:10549447-Humans,
pubmed-meshheading:10549447-Infant,
pubmed-meshheading:10549447-Intrauterine Devices, Copper,
pubmed-meshheading:10549447-Lactation,
pubmed-meshheading:10549447-Male,
pubmed-meshheading:10549447-Milk, Human,
pubmed-meshheading:10549447-Parity,
pubmed-meshheading:10549447-Patient Dropouts,
pubmed-meshheading:10549447-Patient Satisfaction,
pubmed-meshheading:10549447-Progesterone,
pubmed-meshheading:10549447-Radioimmunoassay,
pubmed-meshheading:10549447-Vagina
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Preregistration study on the safety and contraceptive efficacy of a progesterone-releasing vaginal ring in Chilean nursing women.
|
|
pubmed:affiliation |
Instituto Chileno de Medicina Reproductiva, Consultorio de Planificación Familiar, Santiago, Chile.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Controlled Clinical Trial,
Multicenter Study
|
