Linked Life Data

10548328

Source:http://linkedlifedata.com/resource/pubmed/id/10548328

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-12-16
pubmed:abstractText
This paper presents the first application of a novel methodology for nonstationary nonlinear modeling to neurobiological data consisting of extracellular population field potentials recorded from the dendritic layer of the dentate gyrus of the rabbit hippocampus under conditions of stimulus-induced potentiation. The experimental stimulus was a Poisson random sequence with a mean rate of 5 impulses/s applied to the perforant path, which was sufficient to induce a progressive potentiation of perforant path-evoked granule cell response. The modeling method utilizes a novel artificial neural network architecture, which is based on the general time-varying Volterra model. The artificial neural network is composed of parallel subnets of three-layer perceptrons with polynomial activation functions, with the output of each subnet modulated by an appropriate time function that models the system nonstationarities and gives the summative output its time-varying characteristics. For the specific application presented herein these time functions are sigmoidal functions with trainable slopes and inflection points. A possible mapping between the nonstationary components of the model and the mechanisms underlying potentiation changes in the hippocampus is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0090-6964
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
581-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Application of a novel modeling method to the nonstationary properties of potentiation in the rabbit hippocampus.
pubmed:affiliation
Department of Biomedical Engineering, University of Southern California, Los Angeles, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.