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pubmed-article:10547442pubmed:abstractTextThe prnABCD gene cluster from Pseudomonas fluorescens encodes the biosynthetic pathway for pyrrolnitrin, a secondary metabolite derived from tryptophan which has strong anti-fungal activity. We used the prn genes from P. fluorescens strain BL915 as a probe to clone and sequence homologous genes from three other Pseudomonas strains, Burkholderia cepacia and Myxococcus fulvus. With the exception of the prnA gene from M. fulvus59% similar among the strains, indicating that the biochemical pathway for pyrrolnitrin biosynthesis is highly conserved. The prnA gene from M. fulvus is about 45% similar to prnA from the other strains and contains regions which are highly conserved among all six strains.lld:pubmed
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pubmed-article:10547442pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:10547442pubmed:articleTitleConservation of the pyrrolnitrin biosynthetic gene cluster among six pyrrolnitrin-producing strains.lld:pubmed
pubmed-article:10547442pubmed:affiliationNovartis Agribusiness Biotechnology Research, P.O. Box 12257, Research Triangle Park, NC 27709, USA.lld:pubmed
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