rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1999-11-24
|
pubmed:databankReference |
|
pubmed:abstractText |
The prnABCD gene cluster from Pseudomonas fluorescens encodes the biosynthetic pathway for pyrrolnitrin, a secondary metabolite derived from tryptophan which has strong anti-fungal activity. We used the prn genes from P. fluorescens strain BL915 as a probe to clone and sequence homologous genes from three other Pseudomonas strains, Burkholderia cepacia and Myxococcus fulvus. With the exception of the prnA gene from M. fulvus59% similar among the strains, indicating that the biochemical pathway for pyrrolnitrin biosynthesis is highly conserved. The prnA gene from M. fulvus is about 45% similar to prnA from the other strains and contains regions which are highly conserved among all six strains.
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0378-1097
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
180
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
39-44
|
pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10547442-Antifungal Agents,
pubmed-meshheading:10547442-Base Sequence,
pubmed-meshheading:10547442-Blotting, Southern,
pubmed-meshheading:10547442-Burkholderia cepacia,
pubmed-meshheading:10547442-Conserved Sequence,
pubmed-meshheading:10547442-Genes, Bacterial,
pubmed-meshheading:10547442-Molecular Sequence Data,
pubmed-meshheading:10547442-Mutation,
pubmed-meshheading:10547442-Myxococcus,
pubmed-meshheading:10547442-Polymerase Chain Reaction,
pubmed-meshheading:10547442-Pseudomonas,
pubmed-meshheading:10547442-Pyrrolnitrin,
pubmed-meshheading:10547442-Sequence Alignment
|
pubmed:year |
1999
|
pubmed:articleTitle |
Conservation of the pyrrolnitrin biosynthetic gene cluster among six pyrrolnitrin-producing strains.
|
pubmed:affiliation |
Novartis Agribusiness Biotechnology Research, P.O. Box 12257, Research Triangle Park, NC 27709, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|