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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1999-11-30
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pubmed:abstractText |
Gemcitabine, a pyrimidine analogue of deoxycytidine, is an anticancer nucleoside drug that requires functional plasma membrane nucleoside transporter proteins to reach its intracellular targets and cause cytotoxicity. Because of technical difficulties inherent in studying nucleoside transport in human cells, we rigorously defined gemcitabine membrane transportability by producing each of the available human (h) and rat (r) recombinant nucleoside transporters (NTs) individually in Xenopus laevis oocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8874
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1876-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10547395-Animals,
pubmed-meshheading:10547395-Antimetabolites, Antineoplastic,
pubmed-meshheading:10547395-Biological Transport,
pubmed-meshheading:10547395-Carrier Proteins,
pubmed-meshheading:10547395-Cell Membrane,
pubmed-meshheading:10547395-Deoxycytidine,
pubmed-meshheading:10547395-Electrophysiology,
pubmed-meshheading:10547395-Membrane Proteins,
pubmed-meshheading:10547395-Neoplasms,
pubmed-meshheading:10547395-Nucleosides,
pubmed-meshheading:10547395-Oocytes,
pubmed-meshheading:10547395-Recombinant Proteins,
pubmed-meshheading:10547395-Sodium Channels,
pubmed-meshheading:10547395-Uridine,
pubmed-meshheading:10547395-Xenopus laevis
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pubmed:year |
1999
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pubmed:articleTitle |
Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters.
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pubmed:affiliation |
Department of Oncology, University of Alberta, Canada. johnmack@cancerboard.ab.ca
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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