Source:http://linkedlifedata.com/resource/pubmed/id/10546136
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1999-11-19
|
| pubmed:abstractText |
This case report describes a 48-year-old woman patient with variant angina who died because of severe myocardial ischemia and cardiogenic shock, in spite of chronic therapy with nitrates and calcium-antagonists and acute intravenous administration of nitrates, calcium-antagonists and tissue-type plasminogen activator. Her Holter monitoring showed a reduction of time domain measures of heart rate variability. The hemodynamic study exhibited a normal ventriculography and angiographically normal epicardial coronary arteries. The provocative testing, performed (during intravenous therapy with nitrates and diltiazem) by intracoronary injection of progressively increasing doses of ergonovine, induced only a mild vasoconstriction of proximal left anterior descending artery, without symptoms or ST-T segment changes. This case reminds us that variant angina can be a lethal disease, confirms that a negative result of intracoronary ergonovine testing performed during intravenous therapy with nitrates and calcium-antagonists does not assure the prevention of new episodes during chronic oral therapy with the same drugs, suggests a possible prognostic value of the reduction of heart rate variability indexes and shows an unusual response to nitrate administration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Diltiazem,
http://linkedlifedata.com/resource/pubmed/chemical/Ergonovine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Plasminogen Activator,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0046-5968
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1208-11
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10546136-Angina Pectoris, Variant,
pubmed-meshheading:10546136-Calcium Channel Blockers,
pubmed-meshheading:10546136-Coronary Angiography,
pubmed-meshheading:10546136-Diltiazem,
pubmed-meshheading:10546136-Electrocardiography,
pubmed-meshheading:10546136-Electrocardiography, Ambulatory,
pubmed-meshheading:10546136-Ergonovine,
pubmed-meshheading:10546136-Female,
pubmed-meshheading:10546136-Hemodynamics,
pubmed-meshheading:10546136-Humans,
pubmed-meshheading:10546136-Infusions, Intravenous,
pubmed-meshheading:10546136-Middle Aged,
pubmed-meshheading:10546136-Myocardial Ischemia,
pubmed-meshheading:10546136-Nitrates,
pubmed-meshheading:10546136-Prognosis,
pubmed-meshheading:10546136-Shock, Cardiogenic,
pubmed-meshheading:10546136-Tissue Plasminogen Activator,
pubmed-meshheading:10546136-Vasodilator Agents
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
An uncommon case of variant angina.
|
| pubmed:affiliation |
Divisione di Cardiologia, IRCCS H San Raffaele, Milano.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|