Source:http://linkedlifedata.com/resource/pubmed/id/10545679
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-12-21
|
| pubmed:abstractText |
The activation of platelets, leukocytes, and vascular endothelial cells mediated by cell adhesion molecules may play a role in the mechanism of restenosis, which is still a significant complication after coronary angioplasty. We observed serial changes in the circulating soluble forms of adhesion molecules in 25 patients with coronary artery disease who underwent coronary angioplasty for a single lesion of the left anterior descending artery. Serum levels of sICAM-1 (p < 0.05) and sP-selectin (p < 0.05) were significantly increased immediately after angioplasty in the coronary sinus blood samples. These increases continued during the 48-hour observation period, and the maximum increase was seen 48 h after angioplasty for sICAM-1 (p < 0.01) and 24 h after angioplasty for sP-selectin (p < 0. 01). The level of sL-selectin increased 24 h (p < 0.01) and 48 h (p < 0.001) after angioplasty. These changes were not observed in the peripheral blood samples. The sE-selectin level did not change after angioplasty. A multiple regression analysis showed that the late loss index obtained from quantitative angiographic (QCA) analysis was correlated with the changes in sICAM-1 (r = 0.31, p < 0.05), sL-selectin (r = 0.28, p < 0.05), and sP-selectin (r = 0.26, p < 0. 05) 48 h after angioplasty in the coronary sinus blood samples, but was not correlated with procedural variables, other QCA variables, or the change in the sL-selectin level. The measurements of these adhesion molecule levels may help to evaluate traumatic vessel wall injury and inflammation at the intervention site after coronary angioplasty.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/E-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/L-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0008-6312
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
236-42
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:10545679-Analysis of Variance,
pubmed-meshheading:10545679-Angioplasty, Balloon, Coronary,
pubmed-meshheading:10545679-Cell Adhesion Molecules,
pubmed-meshheading:10545679-Coronary Artery Disease,
pubmed-meshheading:10545679-Coronary Vessels,
pubmed-meshheading:10545679-E-Selectin,
pubmed-meshheading:10545679-Endothelium, Vascular,
pubmed-meshheading:10545679-Female,
pubmed-meshheading:10545679-Follow-Up Studies,
pubmed-meshheading:10545679-Humans,
pubmed-meshheading:10545679-Intercellular Adhesion Molecule-1,
pubmed-meshheading:10545679-L-Selectin,
pubmed-meshheading:10545679-Leukocytes,
pubmed-meshheading:10545679-Male,
pubmed-meshheading:10545679-Middle Aged,
pubmed-meshheading:10545679-P-Selectin,
pubmed-meshheading:10545679-Platelet Activation,
pubmed-meshheading:10545679-Recurrence,
pubmed-meshheading:10545679-Regression Analysis,
pubmed-meshheading:10545679-Vasculitis
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Serum levels of circulating adhesion molecules after coronary angioplasty.
|
| pubmed:affiliation |
Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|