Source:http://linkedlifedata.com/resource/pubmed/id/10544508
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-11-16
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| pubmed:abstractText |
Engraftment in relation to infused CD34+ cell number was retrospectively analysed in 66 patients with hematological diseases: non-Hodgkin's lymphoma (n = 33), multiple myeloma (n = 21), acute myelogenous leukemia (n = 7), Hodgkin's disease (n = 4) and myelodysplastic syndrome (n = 1). Progenitor cells were mobilized with rhG-CSF, alone or in association with chemotherapy. The cells were harvested by leukapheresis until at least 2 x 10(6) CD34+/kg body weight were obtained. A total of 194 leukaphereses were performed (median = 3 per patient, range 1-9). A median of 3.40 x 10(8) nucleated cells/kg (range 0.31-27.59) and a median of 7.15 x 10(6) CD34+ cell/kg (range 1.31-115.70) were transplanted. Regardless of transfusional support or patient diagnosis, engraftment was rapid in patients who had received > or = 5 x 10(6) CD34+ cell/kg. In this case, absolute neutrophil blood count > or = 0.5 x 10(9)/l was obtained on day 12 post graft (range 7-19) and platelet count > or = 20 x 10(9)/l was also reached after the same median time interval (range 8-121). From the present results, a minimal threshold of 5 x 10(6) CD34+ cell/kg appears to be suitable for providing rapid and complete hematopoieitc reconstitution in patients exposed to high doses of chemotherapy with or without total body irradiation. Furthermore, administration of rhG-CSF during post-graft period significantly decreased the neutrophil time recovery (P = 0.002) but not that of platelets (P > 0.05).
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| pubmed:language |
fre
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
0001-5512
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
54
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
191-6
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| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10544508-Acute Disease,
pubmed-meshheading:10544508-Adolescent,
pubmed-meshheading:10544508-Adult,
pubmed-meshheading:10544508-Aged,
pubmed-meshheading:10544508-Antigens, CD34,
pubmed-meshheading:10544508-Antineoplastic Agents,
pubmed-meshheading:10544508-Female,
pubmed-meshheading:10544508-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:10544508-Hematologic Neoplasms,
pubmed-meshheading:10544508-Hematopoiesis,
pubmed-meshheading:10544508-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:10544508-Hodgkin Disease,
pubmed-meshheading:10544508-Humans,
pubmed-meshheading:10544508-Leukapheresis,
pubmed-meshheading:10544508-Leukemia, Myeloid,
pubmed-meshheading:10544508-Leukocyte Count,
pubmed-meshheading:10544508-Lymphoma, Non-Hodgkin,
pubmed-meshheading:10544508-Male,
pubmed-meshheading:10544508-Middle Aged,
pubmed-meshheading:10544508-Multiple Myeloma,
pubmed-meshheading:10544508-Myelodysplastic Syndromes,
pubmed-meshheading:10544508-Neutrophils,
pubmed-meshheading:10544508-Platelet Count,
pubmed-meshheading:10544508-Retrospective Studies,
pubmed-meshheading:10544508-Transplantation, Autologous,
pubmed-meshheading:10544508-Transplantation Conditioning,
pubmed-meshheading:10544508-Whole-Body Irradiation
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
[Hematopoietic recovery as a function of the number of autografted CD34+ cells: a retrospective study of 66 patients with malignant hematologic diseases].
|
| pubmed:affiliation |
Laboratoire d'immunohématologie, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgique. Rachid.boulassel@mblg.ucl.ac.be
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| pubmed:publicationType |
Journal Article,
English Abstract
|