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rdf:type |
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lifeskim:mentions |
umls-concept:C0003805,
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0022173,
umls-concept:C0086418,
umls-concept:C0205177,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C1171362,
umls-concept:C1366526,
umls-concept:C1418388,
umls-concept:C1515670,
umls-concept:C2252854
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pubmed:issue |
4
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pubmed:dateCreated |
1999-12-22
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pubmed:abstractText |
The presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate carcinoma (CaP) are still unclear. The aim of the present study was: 1) to evaluate the pattern of androgen metabolism (relative production of 5alpha-reduced vs. 17-keto androgens); and 2) to analyze whether one or both the two known 5alpha-reductase isoforms (5alpha-R1 and 5alpha-R2) and the aromatase (Aro) are expressed and active in this pathology.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-Oxo-5-alpha-Steroid...,
http://linkedlifedata.com/resource/pubmed/chemical/Androgens,
http://linkedlifedata.com/resource/pubmed/chemical/Androstenedione,
http://linkedlifedata.com/resource/pubmed/chemical/Aromatase,
http://linkedlifedata.com/resource/pubmed/chemical/Aromatase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydrotestosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Etiocholanolone,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/anastrozole,
http://linkedlifedata.com/resource/pubmed/chemical/androstane-3,17-dione
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
224-32
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10544295-3-Oxo-5-alpha-Steroid 4-Dehydrogenase,
pubmed-meshheading:10544295-Androgens,
pubmed-meshheading:10544295-Androstenedione,
pubmed-meshheading:10544295-Aromatase,
pubmed-meshheading:10544295-Aromatase Inhibitors,
pubmed-meshheading:10544295-Blotting, Southern,
pubmed-meshheading:10544295-Dihydrotestosterone,
pubmed-meshheading:10544295-Enzyme Inhibitors,
pubmed-meshheading:10544295-Etiocholanolone,
pubmed-meshheading:10544295-Humans,
pubmed-meshheading:10544295-Hydrogen-Ion Concentration,
pubmed-meshheading:10544295-Isoenzymes,
pubmed-meshheading:10544295-Male,
pubmed-meshheading:10544295-Microsomes,
pubmed-meshheading:10544295-Nitriles,
pubmed-meshheading:10544295-Prostatic Hyperplasia,
pubmed-meshheading:10544295-Prostatic Neoplasms,
pubmed-meshheading:10544295-RNA, Messenger,
pubmed-meshheading:10544295-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10544295-Testosterone,
pubmed-meshheading:10544295-Triazoles,
pubmed-meshheading:10544295-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
5alpha-reductase isozymes and aromatase are differentially expressed and active in the androgen-independent human prostate cancer cell lines DU145 and PC3.
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pubmed:affiliation |
Center for Endocrinological Oncology, Department of Endocrinology, University of Milan, Milan, Italy. pnc@mialserver.unimi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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