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pubmed-article:10544237pubmed:abstractTextbeta-Carotene has often been discussed as a means to reduce the risk of skin photodamage. We studied the antioxidative potential of beta-carotene in human skin fibroblasts exposed to ultraviolet A light. Surprisingly, we found a pro-oxidative effect of beta-carotene. Using the induction of haem oxygenase-1 as a marker for oxidative stress, we found a strong enhancement of gene expression by beta-carotene in ultraviolet A-irradiated cells. This effect was clearly suppressed by concomitant addition of vitamin E but only moderately by vitamin C. The results show that beta-carotene has pro-oxidative properties in human skin fibroblasts exposed to ultraviolet-A light.lld:pubmed
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pubmed-article:10544237pubmed:articleTitleEnhancement of the UVA induction of haem oxygenase-1 expression by beta-carotene in human skin fibroblasts.lld:pubmed
pubmed-article:10544237pubmed:affiliationDepartment of Biological Chemistry and Nutrition, University of Hohenheim, Fruwirthstrasse 12, D-70593, Stuttgart, Germany.lld:pubmed
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