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rdf:type |
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lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0018966,
umls-concept:C0053396,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C1123023,
umls-concept:C1627358,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
1999-12-10
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pubmed:abstractText |
beta-Carotene has often been discussed as a means to reduce the risk of skin photodamage. We studied the antioxidative potential of beta-carotene in human skin fibroblasts exposed to ultraviolet A light. Surprisingly, we found a pro-oxidative effect of beta-carotene. Using the induction of haem oxygenase-1 as a marker for oxidative stress, we found a strong enhancement of gene expression by beta-carotene in ultraviolet A-irradiated cells. This effect was clearly suppressed by concomitant addition of vitamin E but only moderately by vitamin C. The results show that beta-carotene has pro-oxidative properties in human skin fibroblasts exposed to ultraviolet-A light.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/HMOX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing),
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/beta Carotene
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
460
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
212-6
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10544237-Antioxidants,
pubmed-meshheading:10544237-Ascorbic Acid,
pubmed-meshheading:10544237-Blotting, Northern,
pubmed-meshheading:10544237-Blotting, Western,
pubmed-meshheading:10544237-Cells, Cultured,
pubmed-meshheading:10544237-DNA, Complementary,
pubmed-meshheading:10544237-Fibroblasts,
pubmed-meshheading:10544237-Heme Oxygenase (Decyclizing),
pubmed-meshheading:10544237-Heme Oxygenase-1,
pubmed-meshheading:10544237-Humans,
pubmed-meshheading:10544237-Membrane Proteins,
pubmed-meshheading:10544237-Oxidants,
pubmed-meshheading:10544237-Oxidative Stress,
pubmed-meshheading:10544237-RNA, Messenger,
pubmed-meshheading:10544237-Skin,
pubmed-meshheading:10544237-Time Factors,
pubmed-meshheading:10544237-Ultraviolet Rays,
pubmed-meshheading:10544237-Vitamin E,
pubmed-meshheading:10544237-beta Carotene
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pubmed:year |
1999
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pubmed:articleTitle |
Enhancement of the UVA induction of haem oxygenase-1 expression by beta-carotene in human skin fibroblasts.
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pubmed:affiliation |
Department of Biological Chemistry and Nutrition, University of Hohenheim, Fruwirthstrasse 12, D-70593, Stuttgart, Germany.
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pubmed:publicationType |
Journal Article
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