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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1999-12-6
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pubmed:abstractText |
In Escherichia coli, the CpxRA two-component signal transduction system senses and responds to aggregated and misfolded proteins in the bacterial envelope. We show that CpxR-P (the phosphorylated form of the cognate response regulator) activates cpxRA expression in conjunction with RpoS, suggesting an involvement of the Cpx system in stationary-phase survival. Engagement of the CpxRA system in functions beyond protein management is indicated by several putative targets identified after a genomic screening for the CpxR-P recognition consensus sequence. Direct negative control of the newly identified targets motABcheAW (specifying motility and chemotaxis) and tsr (encoding the serine chemoreceptor) by CpxR-P was shown by electrophoretic mobility shift analysis and Northern hybridization. The results suggest that the CpxRA system plays a core role in an extensive stress response network in which the coordination of protein turnover and energy conservation may be the unifying element.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-10322173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-2185221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-2504697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-2546916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-2644646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-2691330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-3298218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-353502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-3539185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-3596251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-6090403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-6102380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-6185685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-6339479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-6802799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-6998969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-6998970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-7031054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-7047501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-7050092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-7883164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-7984106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-8432716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-8748033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-9023180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-9159398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-9159399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-9209042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-9294451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-9401031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-9473036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10542180-9642209
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CheW protein, Bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/CheW protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/CpxA protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/CpxA protein, bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/CpxR protein, Bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MotA protein, Bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/MotB protein, Bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Sigma Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tsr protein, Bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/methyl-accepting chemotaxis proteins,
http://linkedlifedata.com/resource/pubmed/chemical/sigma factor KatF protein, Bacteria
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6772-8
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:10542180-Bacterial Proteins,
pubmed-meshheading:10542180-Base Sequence,
pubmed-meshheading:10542180-Escherichia coli,
pubmed-meshheading:10542180-Escherichia coli Proteins,
pubmed-meshheading:10542180-Gene Expression Regulation, Bacterial,
pubmed-meshheading:10542180-Membrane Proteins,
pubmed-meshheading:10542180-Molecular Sequence Data,
pubmed-meshheading:10542180-Operon,
pubmed-meshheading:10542180-Promoter Regions, Genetic,
pubmed-meshheading:10542180-Protein Kinases,
pubmed-meshheading:10542180-Sigma Factor,
pubmed-meshheading:10542180-Signal Transduction
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pubmed:year |
1999
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pubmed:articleTitle |
The CpxRA signal transduction system of Escherichia coli: growth-related autoactivation and control of unanticipated target operons.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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