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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5441
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pubmed:dateCreated |
1999-11-24
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pubmed:abstractText |
The Drosophila Polycomb and trithorax group proteins act through chromosomal elements such as Fab-7 to maintain repressed or active gene expression, respectively. A Fab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription. Here, histone H4 hyperacetylation was found to be associated with Fab-7 after activation, suggesting that H4 hyperacetylation may be a heritable epigenetic tag of the activated element. Activated Fab-7 enables transcription of a gene even after withdrawal of the primary transcription factor. This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GAL4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Polycomb protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Trl protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
955-8
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:10542150-Acetylation,
pubmed-meshheading:10542150-Animals,
pubmed-meshheading:10542150-Animals, Genetically Modified,
pubmed-meshheading:10542150-Chromatin,
pubmed-meshheading:10542150-DNA-Binding Proteins,
pubmed-meshheading:10542150-Drosophila,
pubmed-meshheading:10542150-Drosophila Proteins,
pubmed-meshheading:10542150-Fungal Proteins,
pubmed-meshheading:10542150-Gene Expression Regulation, Developmental,
pubmed-meshheading:10542150-Histones,
pubmed-meshheading:10542150-Insect Proteins,
pubmed-meshheading:10542150-Lac Operon,
pubmed-meshheading:10542150-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:10542150-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:10542150-Trans-Activators,
pubmed-meshheading:10542150-Transcription Factors
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pubmed:year |
1999
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pubmed:articleTitle |
Epigenetic inheritance of active chromatin after removal of the main transactivator.
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pubmed:affiliation |
Zentrum für Molekulare Biologie (ZMBH), Universität of Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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