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rdf:type |
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lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0006104,
umls-concept:C0007776,
umls-concept:C0022655,
umls-concept:C0033684,
umls-concept:C0039729,
umls-concept:C0085255,
umls-concept:C0205147,
umls-concept:C0392756,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1419206,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
1
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pubmed:dateCreated |
1999-11-30
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pubmed:abstractText |
Two synaptic-vesicle proteins, rab3a and synaptophysin, have been studied on post-mortem brain tissues of schizophrenics and healthy controls. We found significantly reduced levels of rab3a in thalamus (p<0.001); for both proteins in gyrus cinguli and hippocampus (p<0.0001); for rab3a in frontal and parietal cortex (p<0.05); and no differences in temporal cortex or cerebellum in schizophrenics compared with controls. Reduced synaptic density may be a prominent feature of the molecular neuropathology of schizophrenia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0920-9964
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-9
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:10541003-Adult,
pubmed-meshheading:10541003-Aged,
pubmed-meshheading:10541003-Biological Markers,
pubmed-meshheading:10541003-Blotting, Western,
pubmed-meshheading:10541003-Cerebellum,
pubmed-meshheading:10541003-Cerebral Cortex,
pubmed-meshheading:10541003-Exocytosis,
pubmed-meshheading:10541003-Female,
pubmed-meshheading:10541003-Gyrus Cinguli,
pubmed-meshheading:10541003-Hippocampus,
pubmed-meshheading:10541003-Humans,
pubmed-meshheading:10541003-Male,
pubmed-meshheading:10541003-Middle Aged,
pubmed-meshheading:10541003-Prospective Studies,
pubmed-meshheading:10541003-Schizophrenia,
pubmed-meshheading:10541003-Synaptic Vesicles,
pubmed-meshheading:10541003-Synaptophysin,
pubmed-meshheading:10541003-Thalamus,
pubmed-meshheading:10541003-rab3A GTP-Binding Protein
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pubmed:year |
1999
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pubmed:articleTitle |
The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains.
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pubmed:affiliation |
Institute of Clinical Neuroscience, Göteborg University, Sahlgrenska University Hospital/Mölndal, Mölndal, Sweden. pia.davidsson@ms.se
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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