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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-11-8
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pubmed:abstractText |
Atrial natriuretic peptide (ANP) lowers arterial blood pressure (ABP) chronically, in association with vasodilation of the resistance vasculature. The mechanism mediating the chronic relaxant effect of ANP is likely indirectly mediated by interactions with tonic vasoeffector mechanisms, inasmuch as the resistance vasculature is relatively insensitive to direct cGMP-mediated relaxation by ANP. On the basis of evidence that ANP has widespread sympatholytic activity, the current study investigated whether the chronic hypotensive effect of ANP is mediated by attenuation of tonic cardiovascular sympathetic tone.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
437-44
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10536674-Analysis of Variance,
pubmed-meshheading:10536674-Animals,
pubmed-meshheading:10536674-Atrial Natriuretic Factor,
pubmed-meshheading:10536674-Blood Pressure,
pubmed-meshheading:10536674-Epinephrine,
pubmed-meshheading:10536674-Ganglionic Blockers,
pubmed-meshheading:10536674-Heart Rate,
pubmed-meshheading:10536674-Hexamethonium,
pubmed-meshheading:10536674-Male,
pubmed-meshheading:10536674-Mice,
pubmed-meshheading:10536674-Mice, Inbred DBA,
pubmed-meshheading:10536674-Mice, Knockout,
pubmed-meshheading:10536674-Mice, Transgenic,
pubmed-meshheading:10536674-Norepinephrine,
pubmed-meshheading:10536674-Protein Binding,
pubmed-meshheading:10536674-Receptors, Adrenergic,
pubmed-meshheading:10536674-Sympathomimetics
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pubmed:year |
1999
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pubmed:articleTitle |
Chronic regulation of arterial blood pressure in ANP transgenic and knockout mice: role of cardiovascular sympathetic tone.
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pubmed:affiliation |
Department of Physiology, University of Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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