Linked Life Data

1053518

Source:http://linkedlifedata.com/resource/pubmed/id/1053518

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-4-9
pubmed:abstractText
Imaging maternal and fetal circulation during perfusion of isolated human placental lobules was performed. Radionuclide and contrast angiograms, specimen scans, and histologic preparations obtained on human material during in vitro investigations were compared to the results obtained in vivo on pregnant rhesus monkeys. The distribution of maternal blood flow within the placenta appeared similar in both human and rhesus studies. The 'spurts' of radiopaque medium shown on the contrast angiograms correlated with the appearance of areas of increased radioactivity. These 'hot spots' are located where the uteroplacental spiral arteries open into the intervillous space or where the perfusion cannulae irrigate the maternal side of the placenta. Time-radioactivity curves reached an early peak and remained the same as did their distribution on delayed scans. The 15 to 30 micron microspheres injected into the intervillous spaces are not removed onto the venous side by maternal flow through arteriovenous communications (or 'shunts') but are retained in localized areas of the intervillous space adjacent to the spiral arteries. Many of these microspheres adhere to the 'brush border' of the chorionic villi syncytiotrophoblast. These comparative studies confirm that rhesus monkeys and perfused human placental lobules are relevant models to investigate uteroplacental hemodynamics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0301-2115
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Radionuclide and angiographic studies of placental circulation in man and rhesus monkey.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't