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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-12-17
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pubmed:abstractText |
To understand the relative efficacy of noradrenergic and serotonergic antidepressants as analgesics in chronic back pain without depression, we conducted a randomized, double-blind, placebo-control head-to-head comparison of maprotiline (a norepinephrine reuptake blocker) and paroxetine (a serotonin reuptake blocker) in 103 patients with chronic low back pain. Of these 74 completed the trial; of the 29 who did not complete, 19 were withdrawn because of adverse effects. The intervention consisted of an 8-week course of maprotiline (up to 150 mg daily) or paroxetine (up to 30 mg daily) or an active placebo, diphenhydramine hydrochloride (up to 37.5 mg daily). Patients were excluded for current major depression. Reduction in pain intensity (Descriptor Differential Scale scores) was significantly greater for study completers randomized to maprotiline compared to placebo (P=0.023), and to paroxetine (P=0.013), with a reduction of pain by 45% compared to 27% on placebo and 26% on paroxetine. These results suggest that at standard dosages noradrenergic agents may provide more effective analgesia in back pain than do selective serotonergic reuptake inhibitors.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0304-3959
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pubmed:author |
pubmed-author:AbramsonII,
pubmed-author:AtkinsonJ HJH,
pubmed-author:Epping-JordanJ EJE,
pubmed-author:GardazP CPC,
pubmed-author:GrandYY,
pubmed-author:PattersonT LTL,
pubmed-author:PruittS DSD,
pubmed-author:SlaterM AMA,
pubmed-author:WahlgrenD RDR,
pubmed-author:WilliamsR ARA,
pubmed-author:ZisookSS
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-45
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10534584-Adrenergic Uptake Inhibitors,
pubmed-meshheading:10534584-Adult,
pubmed-meshheading:10534584-Aged,
pubmed-meshheading:10534584-Chronic Disease,
pubmed-meshheading:10534584-Diphenhydramine,
pubmed-meshheading:10534584-Double-Blind Method,
pubmed-meshheading:10534584-Humans,
pubmed-meshheading:10534584-Hypnotics and Sedatives,
pubmed-meshheading:10534584-Low Back Pain,
pubmed-meshheading:10534584-Maprotiline,
pubmed-meshheading:10534584-Middle Aged,
pubmed-meshheading:10534584-Pain Measurement,
pubmed-meshheading:10534584-Paroxetine,
pubmed-meshheading:10534584-Patient Selection,
pubmed-meshheading:10534584-Placebos,
pubmed-meshheading:10534584-Serotonin Uptake Inhibitors
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pubmed:year |
1999
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pubmed:articleTitle |
Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity.
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pubmed:affiliation |
Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0603, USA. jhatkinson@ucsd.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial,
Multicenter Study
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