Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-12-9
pubmed:databankReference
pubmed:abstractText
We report the cloning and characterization of the human eukaryotic protein translation initiation factor EIF2C1 gene. The human EIF2C1 gene consists of 19 exons and 18 introns that span a region of almost 50 kb. It is located on the short arm of chromosome 1 in the region 1p34-p35. This genomic region is frequently lost in human cancers such as Wilms tumors, neuroblastoma, and carcinomas of the breast, liver, and colon. The human EIF2C1 gene is ubiquitously expressed at low to medium levels. Differential polyadenylation and splicing result in a complex transcriptional pattern. The cDNA sequence is 7478 bp long and contains an extremely large 3' untranslated region of 4799 bp with multiple, short repeated segments composed of mono-, tri-, or quattronucleotides interspersed throughout. The human EIF2C1 gene belongs to a multigene family in human. It is highly conserved during evolution, sharing about 90% identity with rabbit eIF2C and 70% identity with plant AGO1 at the amino acid level. These facts suggest that human EIF2C1 might play an important physiological role.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0888-7543
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
210-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10534406-Adult, pubmed-meshheading:10534406-Amino Acid Sequence, pubmed-meshheading:10534406-Argonaute Proteins, pubmed-meshheading:10534406-Base Sequence, pubmed-meshheading:10534406-Blotting, Northern, pubmed-meshheading:10534406-Chromosome Banding, pubmed-meshheading:10534406-Chromosome Mapping, pubmed-meshheading:10534406-Chromosomes, Human, Pair 1, pubmed-meshheading:10534406-Cloning, Molecular, pubmed-meshheading:10534406-Conserved Sequence, pubmed-meshheading:10534406-Eukaryotic Initiation Factors, pubmed-meshheading:10534406-Female, pubmed-meshheading:10534406-Fetus, pubmed-meshheading:10534406-Humans, pubmed-meshheading:10534406-In Situ Hybridization, Fluorescence, pubmed-meshheading:10534406-Molecular Sequence Data, pubmed-meshheading:10534406-Peptide Initiation Factors, pubmed-meshheading:10534406-RNA, Messenger, pubmed-meshheading:10534406-Sequence Alignment, pubmed-meshheading:10534406-Transcription, Genetic
pubmed:year
1999
pubmed:articleTitle
Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.
pubmed:affiliation
Institute of Clinical Pathology, Department of Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, Zurich, 8091, Switzerland. R.Koesters@dkfz-heidelberg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't