| pubmed-article:10531285 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10531285 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:10531285 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:10531285 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10531285 | lifeskim:mentions | umls-concept:C0041221 | lld:lifeskim |
| pubmed-article:10531285 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:10531285 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:10531285 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10531285 | pubmed:dateCreated | 1999-11-16 | lld:pubmed |
| pubmed-article:10531285 | pubmed:abstractText | Glycoinositolphospholipids (GIPLs) are some of the major glycolipids of the Trypanosoma cruzi surface that were previously shown to activate B cells. In the present study, we investigated whether (i) T. cruzi GIPLs could induce immunoglobulin secretion from B cells in the absence of T cells and NK cells and whether (ii) NK cells are also stimulated by the GIPLs. B cells purified from mice deficient in both T and NK cells (CD3epsilon transgenic mice) secreted immunoglobulin in response to the GIPL. This response was increased by coculture with a murine NK cell line. The T. cruzi GIPL also increased the NK cell (interleukin-2 induced) proliferative response. Our data indicate that the T. cruzi GIPL has a direct stimulatory effect on NK cells and induces immunoglobulin secretion in the absence of T lymphocytes and NK cells. These findings suggest that this T. cruzi-derived molecule may be one of the stimulators that lead to NK cell activation during T. cruzi infection. | lld:pubmed |
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| pubmed-article:10531285 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10531285 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10531285 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10531285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10531285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10531285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10531285 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10531285 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10531285 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:10531285 | pubmed:author | pubmed-author:MondJ JJJ | lld:pubmed |
| pubmed-article:10531285 | pubmed:author | pubmed-author:PreviatoJ OJO | lld:pubmed |
| pubmed-article:10531285 | pubmed:author | pubmed-author:VosQQ | lld:pubmed |
| pubmed-article:10531285 | pubmed:author | pubmed-author:PeçanhaL MLM | lld:pubmed |
| pubmed-article:10531285 | pubmed:author | pubmed-author:PreviatoL MLM | lld:pubmed |
| pubmed-article:10531285 | pubmed:author | pubmed-author:De Arruda... | lld:pubmed |
| pubmed-article:10531285 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10531285 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:10531285 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10531285 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10531285 | pubmed:pagination | 6177-80 | lld:pubmed |
| pubmed-article:10531285 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10531285 | pubmed:meshHeading | pubmed-meshheading:10531285... | lld:pubmed |
| pubmed-article:10531285 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10531285 | pubmed:articleTitle | Modulation of B-lymphocyte and NK cell activities by glycoinositolphospholipid purified from Trypanosoma cruzi. | lld:pubmed |
| pubmed-article:10531285 | pubmed:affiliation | Department of Immunology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. | lld:pubmed |
| pubmed-article:10531285 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10531285 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10531285 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10531285 | lld:pubmed |
