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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1999-11-16
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pubmed:abstractText |
Glycoinositolphospholipids (GIPLs) are some of the major glycolipids of the Trypanosoma cruzi surface that were previously shown to activate B cells. In the present study, we investigated whether (i) T. cruzi GIPLs could induce immunoglobulin secretion from B cells in the absence of T cells and NK cells and whether (ii) NK cells are also stimulated by the GIPLs. B cells purified from mice deficient in both T and NK cells (CD3epsilon transgenic mice) secreted immunoglobulin in response to the GIPL. This response was increased by coculture with a murine NK cell line. The T. cruzi GIPL also increased the NK cell (interleukin-2 induced) proliferative response. Our data indicate that the T. cruzi GIPL has a direct stimulatory effect on NK cells and induces immunoglobulin secretion in the absence of T lymphocytes and NK cells. These findings suggest that this T. cruzi-derived molecule may be one of the stimulators that lead to NK cell activation during T. cruzi infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-1346796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-1447177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-15275046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-1730271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-2406236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-2452184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-3086453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-3495594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-3873071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-6690619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-6790614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-6802927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-7513725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-7612238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-7700380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-7705404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-7751617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-7937778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-7969447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-8543814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-8557330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-8757300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-8805617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-8943406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-8981087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-9469412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-9558060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-9597134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-9723695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531285-9794425
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6177-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10531285-Animals,
pubmed-meshheading:10531285-B-Lymphocytes,
pubmed-meshheading:10531285-Cell Line,
pubmed-meshheading:10531285-Glycoconjugates,
pubmed-meshheading:10531285-Immunoglobulin M,
pubmed-meshheading:10531285-Interleukin-2,
pubmed-meshheading:10531285-Killer Cells, Natural,
pubmed-meshheading:10531285-Lymphocyte Activation,
pubmed-meshheading:10531285-Mice,
pubmed-meshheading:10531285-Mice, Transgenic,
pubmed-meshheading:10531285-Phosphatidylinositols,
pubmed-meshheading:10531285-Trypanosoma cruzi
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pubmed:year |
1999
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pubmed:articleTitle |
Modulation of B-lymphocyte and NK cell activities by glycoinositolphospholipid purified from Trypanosoma cruzi.
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pubmed:affiliation |
Department of Immunology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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