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rdf:type |
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lifeskim:mentions |
umls-concept:C0021760,
umls-concept:C0041296,
umls-concept:C0042196,
umls-concept:C0042210,
umls-concept:C0123759,
umls-concept:C0205263,
umls-concept:C0332307,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1711351,
umls-concept:C2911692
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pubmed:issue |
11
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pubmed:dateCreated |
1999-11-16
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pubmed:abstractText |
We examined the role of cytokines in the development of gamma interferon (IFN-gamma)-secreting protective T cells following immunization with a culture filtrate subunit vaccine against Mycobacterium tuberculosis containing the adjuvant dimethyldioctadecylammonium bromide (DDA). Depletion of either interleukin-6 (IL-6) or IL-12 with specific neutralizing antibodies during vaccination reduced the priming of T cells for antigen-specific proliferation and IFN-gamma secretion. Such reduction was also observed in IL-6 gene-disrupted mice as compared to wild-type animals. IL-6 was found to play a role in the initial differentiation of Th1 cells but not in their expansion. The defect found after IL-6 depletion or in IL-6-knockout mice was compensated by the inclusion of recombinant mouse IL-12 in the vaccine. The induction of protective immunity against an intravenous or an aerosol challenge with live, virulent M. tuberculosis was markedly reduced by neutralizing either IL-6 or IL-12 during immunization with the vaccine. Likewise, the effects of IL-6 neutralization were partially reversed by including IL-12 in the vaccine. Our data point to an important role of IL-6 and IL-12 in the generation of cell-mediated immunity to tuberculosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1296597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1328056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1381315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1385765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1398989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1431108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1439129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1706379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1733641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1900811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1901893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1902175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1903768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1972166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-1977837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-2120128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-2407536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-2528583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-2842397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-7477296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-7504064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-7612223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-7768607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-7790102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-7910595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-7959868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8127368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8188380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8189056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8205640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8245795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8500900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8501346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8666893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8766574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8871652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-8977207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9009322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9042423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9053446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9075932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9104805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9120387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9120388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9353074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9354477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9414293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9485207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9529155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9596772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10531224-9820535
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5747-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10531224-Animals,
pubmed-meshheading:10531224-Mice,
pubmed-meshheading:10531224-Quaternary Ammonium Compounds,
pubmed-meshheading:10531224-Mycobacterium tuberculosis,
pubmed-meshheading:10531224-Vaccination,
pubmed-meshheading:10531224-Female,
pubmed-meshheading:10531224-BCG Vaccine,
pubmed-meshheading:10531224-Mice, Inbred C57BL,
pubmed-meshheading:10531224-T-Lymphocytes,
pubmed-meshheading:10531224-Interferon-gamma,
pubmed-meshheading:10531224-Interleukin-6
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