Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1999-11-22
pubmed:abstractText
In order to study the role of metabotropic glutamate 1 (mGlu1) receptors in ischemic neuronal death, we examined the effects of the recently characterized and relatively selective mGlu1 receptor antagonists 1-aminoindan-1,5-dicarboxylic acid (AIDA) and (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine (CBPG) in murine cortical cell cultures and rat organotypic hippocampal slices exposed to oxygen glucose deprivation (OGD) and in vivo, following transient global ischemia in gerbils. AIDA and CBPG significantly reduced neuronal death when added to the incubation medium during the OGD insult and the subsequent recovery period. Neuroprotection was observed even when these compounds were added up to 60 min (in cortical neurons) or 30 min (in hippocampal slices) after OGD. In vivo, i.c.v. administration of AIDA and CBPG reduced hippocampal CA1 pyramidal cell injury following transient global ischemia. Neuroprotection was also observed when AIDA was added to the hippocampal perfusion fluid in microdialysis experiments, and this effect was associated with an increase in the basal output of GABA. These findings demonstrate that AIDA and CBPG are neuroprotective when administered during the maturation of ischemic damage and that different mechanisms are likely to be involved in mediating their effects following blockade of mGlu1 receptors in cortical and hippocampal neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/1-aminoindan-1,5-dicarboxylic acid, http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate, http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Glucose, http://linkedlifedata.com/resource/pubmed/chemical/Glycine, http://linkedlifedata.com/resource/pubmed/chemical/Indans, http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate, http://linkedlifedata.com/resource/pubmed/chemical/UPF 596, http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor...
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1607-19
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10530822-Animals, pubmed-meshheading:10530822-Bicyclo Compounds, pubmed-meshheading:10530822-Cell Hypoxia, pubmed-meshheading:10530822-Cells, Cultured, pubmed-meshheading:10530822-Cerebral Cortex, pubmed-meshheading:10530822-Coculture Techniques, pubmed-meshheading:10530822-Dizocilpine Maleate, pubmed-meshheading:10530822-Excitatory Amino Acid Antagonists, pubmed-meshheading:10530822-Fetus, pubmed-meshheading:10530822-Gerbillinae, pubmed-meshheading:10530822-Glucose, pubmed-meshheading:10530822-Glycine, pubmed-meshheading:10530822-Hippocampus, pubmed-meshheading:10530822-Indans, pubmed-meshheading:10530822-Ischemic Attack, Transient, pubmed-meshheading:10530822-Mice, pubmed-meshheading:10530822-Neuroglia, pubmed-meshheading:10530822-Neurons, pubmed-meshheading:10530822-Neuroprotective Agents, pubmed-meshheading:10530822-Rats, pubmed-meshheading:10530822-Receptors, Metabotropic Glutamate
pubmed:year
1999
pubmed:articleTitle
Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms.
pubmed:affiliation
Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze, Italy. dompel@server1.pharm.unifi.it
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't