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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1999-11-22
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pubmed:abstractText |
To get an insight into the bioactive conformation of glutamic acid and its topological environment at the mGluR4 binding site, a pharmacophore model was constructed using molecular modeling. Agonists of known activities were used to run the Apex-3D program or to validate the resulting model. An extended glutamate conformer, two selective hydrophilic sites and bulk tolerance regions are disclosed. Selective features of mGluR1, mGluR2 and mGluR4 are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-3908
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1543-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10530816-Animals,
pubmed-meshheading:10530816-Binding Sites,
pubmed-meshheading:10530816-Excitatory Amino Acid Agonists,
pubmed-meshheading:10530816-Glutamic Acid,
pubmed-meshheading:10530816-Humans,
pubmed-meshheading:10530816-Ligands,
pubmed-meshheading:10530816-Models, Molecular,
pubmed-meshheading:10530816-Molecular Conformation,
pubmed-meshheading:10530816-Protein Conformation,
pubmed-meshheading:10530816-Receptors, Metabotropic Glutamate,
pubmed-meshheading:10530816-Structure-Activity Relationship
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pubmed:year |
1999
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pubmed:articleTitle |
Extended glutamate activates metabotropic receptor types 1, 2 and 4: selective features at mGluR4 binding site.
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pubmed:affiliation |
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR8601-CNRS, Université René Descartes-Paris V, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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