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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1999-11-5
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pubmed:abstractText |
Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression levels in follicular neoplasm (P = 0.00005) and thyroiditis group (P = 0.0037) were significantly higher than that of the control group, while papillary carcinoma group did not show statistical significance. Immunohistochemistry indicated that Prx I was in epithelial cells of thyroid follicles. These results suggest that Prx I is expected to be a candidate for novel tumor markers to discriminate tissue types of tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-32
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10530780-Adult,
pubmed-meshheading:10530780-Aged,
pubmed-meshheading:10530780-Aged, 80 and over,
pubmed-meshheading:10530780-Antioxidants,
pubmed-meshheading:10530780-Case-Control Studies,
pubmed-meshheading:10530780-Female,
pubmed-meshheading:10530780-Humans,
pubmed-meshheading:10530780-Hydrogen Peroxide,
pubmed-meshheading:10530780-Immunoblotting,
pubmed-meshheading:10530780-Immunohistochemistry,
pubmed-meshheading:10530780-Male,
pubmed-meshheading:10530780-Middle Aged,
pubmed-meshheading:10530780-Oxidative Stress,
pubmed-meshheading:10530780-Peroxidases,
pubmed-meshheading:10530780-Peroxiredoxins,
pubmed-meshheading:10530780-Reactive Oxygen Species,
pubmed-meshheading:10530780-Thyroid Gland,
pubmed-meshheading:10530780-Thyroid Neoplasms,
pubmed-meshheading:10530780-Thyroiditis,
pubmed-meshheading:10530780-Thyroxine
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pubmed:year |
1999
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pubmed:articleTitle |
Peroxiredoxin I expression in human thyroid tumors.
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pubmed:affiliation |
Division of Head and Neck Surgery, Chiba Cancer Center Hospital, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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