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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-12-6
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pubmed:abstractText |
In this study, the effect of a phosphorothioated A(1) adenosine receptor antisense oligodeoxynucleotide on A(1) receptor density and mRNA in the striatum and cortex of rats was determined. Receptor autoradiography and in situ hybridization revealed a reduction in striatal and cortical A(1) receptor density and cortical A(1) receptor mRNA, respectively, in antisense-treated brains but not in those treated with a mismatch oligonucleotide. There was no change in A(2) receptor binding. These data imply that the corticostriatal pathway synthesizes A(1) receptors and transports them to its terminals.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
226-30
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10529481-Adenosine,
pubmed-meshheading:10529481-Animals,
pubmed-meshheading:10529481-Autoradiography,
pubmed-meshheading:10529481-Axonal Transport,
pubmed-meshheading:10529481-Cerebral Cortex,
pubmed-meshheading:10529481-Corpus Striatum,
pubmed-meshheading:10529481-Depression, Chemical,
pubmed-meshheading:10529481-Diffusion,
pubmed-meshheading:10529481-Gene Expression Regulation,
pubmed-meshheading:10529481-In Situ Hybridization,
pubmed-meshheading:10529481-Injections,
pubmed-meshheading:10529481-Male,
pubmed-meshheading:10529481-Nerve Tissue Proteins,
pubmed-meshheading:10529481-Oligodeoxyribonucleotides, Antisense,
pubmed-meshheading:10529481-RNA, Messenger,
pubmed-meshheading:10529481-Rats,
pubmed-meshheading:10529481-Rats, Sprague-Dawley,
pubmed-meshheading:10529481-Receptors, Purinergic P1,
pubmed-meshheading:10529481-Thionucleotides
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pubmed:year |
1999
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pubmed:articleTitle |
Autoradiographic evidence that intrastriatal administration of adenosine A(1) receptor antisense oligodeoxynucleotide decreases adenosine A(1) receptors in the rat striatum and cortex.
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pubmed:affiliation |
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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