Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1999-12-17
pubmed:abstractText
The analysis of mice mutant for both Hoxa1 and Hoxb1 suggests that these two genes function together to pattern the hindbrain. Separately, mutations in Hoxa1 and Hoxb1 have profoundly different effects on hindbrain development. Hoxa1 mutations disrupt the rhombomeric organization of the hindbrain, whereas Hoxb1 mutations do not alter the rhombomeric pattern, but instead influence the fate of cells originating in rhombomere 4. We suggest that these differences are not the consequences of different functional roles for these gene products, but rather reflect differences in the kinetics of Hoxa1 and Hoxb1 gene expression. In strong support of the idea that Hoxa1 and Hoxb1 have overlapping functions, Hoxa1/Hoxb1 double mutant homozygotes exhibit a plethora of defects either not seen, or seen only in a very mild form, in mice mutant for only Hoxa1 or Hoxb1. Examples include: the loss of both rhombomeres 4 and 5, the selective loss of the 2(nd) branchial arch, and the loss of most, but not all, 2(nd) branchial arch-derived tissues. We suggest that the early role for both of these genes in hindbrain development is specification of rhombomere identities and that the aberrant development of the hindbrain in Hoxa1/Hoxb1 double mutants proceeds through two phases, the misspecification of rhombomeres within the hindbrain, followed subsequently by size regulation of the misspecified hindbrain through induction of apoptosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 2, http://linkedlifedata.com/resource/pubmed/chemical/Egr2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Fetal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/HOXB1 homeodomain protein, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hoxb2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/MafB Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Mafb protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, EphA4, http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-2, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/homeobox A1 protein, http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid binding protein I...
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5027-40
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10529420-Animals, pubmed-meshheading:10529420-Apoptosis, pubmed-meshheading:10529420-Avian Proteins, pubmed-meshheading:10529420-Branchial Region, pubmed-meshheading:10529420-Craniofacial Abnormalities, pubmed-meshheading:10529420-DNA-Binding Proteins, pubmed-meshheading:10529420-Early Growth Response Protein 2, pubmed-meshheading:10529420-Embryonic and Fetal Development, pubmed-meshheading:10529420-Fetal Proteins, pubmed-meshheading:10529420-Genotype, pubmed-meshheading:10529420-Homeodomain Proteins, pubmed-meshheading:10529420-MafB Transcription Factor, pubmed-meshheading:10529420-Mice, pubmed-meshheading:10529420-Mice, Mutant Strains, pubmed-meshheading:10529420-Motor Neurons, pubmed-meshheading:10529420-Mutation, pubmed-meshheading:10529420-Oncogene Proteins, pubmed-meshheading:10529420-Receptor, EphA4, pubmed-meshheading:10529420-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:10529420-Receptors, Retinoic Acid, pubmed-meshheading:10529420-Rhombencephalon, pubmed-meshheading:10529420-Transcription Factor AP-2, pubmed-meshheading:10529420-Transcription Factors
pubmed:year
1999
pubmed:articleTitle
Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development.
pubmed:affiliation
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.