Linked Life Data

10528184

Source:http://linkedlifedata.com/resource/pubmed/id/10528184

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1999-11-19
pubmed:abstractText
4-1BB ligand (4-1BBL) is a member of the TNF family expressed on activated APC. 4-1BBL binds to 4-1BB (CD137) on activated CD4 and CD8 T cells and in conjunction with strong signals through the TCR provides a CD28-independent costimulatory signal leading to high level IL-2 production by primary resting T cells. Here we report the immunological characterization of mice lacking 4-1BBL and of mice lacking both 4-1BBL and CD28. 4-1BBL-/- mice mount neutralizing IgM and IgG responses to vesicular stomatitis virus that are indistinguishable from those of wild-type mice. 4-1BBL-/- mice show unimpaired CTL responses to lymphocytic choriomeningitis virus (LCMV) and exhibit normal skin allograft rejection but have a weaker CTL response to influenza virus than wild-type mice. 4-1BBL-/-CD28-/- mice retain the CTL response to LCMV, respond poorly to influenza virus, and exhibit a delay in skin allograft rejection. In agreement with these in vivo results, allogeneic CTL responses of CD28-/- but not CD28+/+ T cells to 4-1BBL-expressing APC are substantially inhibited by soluble 4-1BB receptor as is the in vitro secondary response of CD28+ T cells to influenza virus peptides. TCR-transgenic CD28-/- LCMV glycoprotein-specific T cells are insensitive to the presence of 4-1BBL when a wild-type peptide is used, but the response to a weak agonist peptide is greatly augmented by the presence of 4-1BBL. These results further substantiate the idea that different immune responses vary in their dependence on costimulation and suggest a role for 4-1BBL in augmenting suboptimal CTL responses in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4833-41
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10528184-4-1BB Ligand, pubmed-meshheading:10528184-Animals, pubmed-meshheading:10528184-Antibodies, Viral, pubmed-meshheading:10528184-Antigens, CD28, pubmed-meshheading:10528184-Cytotoxicity, Immunologic, pubmed-meshheading:10528184-Female, pubmed-meshheading:10528184-Gene Targeting, pubmed-meshheading:10528184-Graft Rejection, pubmed-meshheading:10528184-Influenza A virus, pubmed-meshheading:10528184-Ligands, pubmed-meshheading:10528184-Lymphocytic choriomeningitis virus, pubmed-meshheading:10528184-Male, pubmed-meshheading:10528184-Mice, pubmed-meshheading:10528184-Mice, Inbred A, pubmed-meshheading:10528184-Mice, Inbred BALB C, pubmed-meshheading:10528184-Mice, Inbred C57BL, pubmed-meshheading:10528184-Mice, Knockout, pubmed-meshheading:10528184-Mice, Transgenic, pubmed-meshheading:10528184-Skin Transplantation, pubmed-meshheading:10528184-T-Lymphocytes, Cytotoxic, pubmed-meshheading:10528184-Tumor Cells, Cultured, pubmed-meshheading:10528184-Tumor Necrosis Factor-alpha, pubmed-meshheading:10528184-Vesicular stomatitis Indiana virus
pubmed:year
1999
pubmed:articleTitle
Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus.
pubmed:affiliation
Department of Immunology, University of Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't