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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-11-19
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pubmed:abstractText |
alpha-Galactosylceramide (alpha-GalCer) is a glycolipid with potent antitumor properties that binds to CD1d molecules and activates mouse Valpha14 and human Valpha24 NKT cells. Surprisingly, we found that, as early as 90 min after alpha-GalCer injection in vivo, NK cells also displayed considerable signs of activation, including IFN-gamma production and CD69 induction. NK activation was not observed in RAG- or CD1-deficient mice, and it was decreased by pretreatment with anti-IFN-gamma Abs, suggesting that, despite its rapid induction, it was a secondary event that depended on IFN-gamma release by NKT cells. At later time points, B cells and CD8 T cells also began to express CD69. These findings identify a high-speed communication network between the innate and adaptive immune systems in vivo that is initiated upon NKT cell activation. They also suggest that the antitumor effects of alpha-GalCer result from the sequential recruitment of distinct innate and adaptive effector lymphocytes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Galactosylceramides,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4647-50
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10528160-Animals,
pubmed-meshheading:10528160-Antigens, CD,
pubmed-meshheading:10528160-Antigens, CD1,
pubmed-meshheading:10528160-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:10528160-Cell Communication,
pubmed-meshheading:10528160-Galactosylceramides,
pubmed-meshheading:10528160-Immunity, Innate,
pubmed-meshheading:10528160-Injections, Intravenous,
pubmed-meshheading:10528160-Interferon-gamma,
pubmed-meshheading:10528160-Killer Cells, Natural,
pubmed-meshheading:10528160-Lectins, C-Type,
pubmed-meshheading:10528160-Lymphocyte Activation,
pubmed-meshheading:10528160-Mice,
pubmed-meshheading:10528160-Mice, Inbred C57BL,
pubmed-meshheading:10528160-Mice, Inbred Strains,
pubmed-meshheading:10528160-Mice, Knockout,
pubmed-meshheading:10528160-Signal Transduction,
pubmed-meshheading:10528160-T-Lymphocyte Subsets
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pubmed:year |
1999
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pubmed:articleTitle |
Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells.
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pubmed:affiliation |
Department of Molecular Biology, Princeton University, NJ 08544, USA. carnaud@infobiogen.fr
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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