Source:http://linkedlifedata.com/resource/pubmed/id/10526194
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-12-16
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pubmed:abstractText |
Griffin and colleagues (Griffin JW, Li CY, Ho TW, Tian M, Gao CY, Xue P, Mishu B, Cornblath DR, Macko C, McKhann GM, Asbury AK. Pathology of motor-sensory axonal Guillain-Barré syndrome. Ann Neurol 1996;39:17-28 [4]) proposed that acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN) are part of the spectrum of a single type of immune attack on the axon. In contrast, IgG anti-GM1 antibody is associated closely with AMAN, but whether other IgG anti-ganglioside antibodies are associated with this neuropathy is not clear. We investigated whether IgG anti-ganglioside antibodies can be used as immunological markers to differentiate AMAN from acute inflammatory demyelinating polyneuropathy (AIDP) and whether these autoantibodies are present in AMSAN. The frequencies of anti-GM1, anti-GM1b, and anti-GD1a IgG antibodies in 21 AMAN patients were significantly higher than in 19 AIDP patients. Anti-GM1b and anti-GD1a IgG, as well as anti-GM1 IgG antibodies, therefore are immunological markers for AMAN. The patients with AMSAN had anti-GM1, anti-GM1b, and anti-GD1a IgG antibodies, indicative that AMAN and AMSAN share a common immunological profile.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/G(M1) Ganglioside,
http://linkedlifedata.com/resource/pubmed/chemical/Gangliosides,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/ganglioside, GD1a,
http://linkedlifedata.com/resource/pubmed/chemical/ganglioside M1b
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-510X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10526194-Adolescent,
pubmed-meshheading:10526194-Adult,
pubmed-meshheading:10526194-Aged,
pubmed-meshheading:10526194-Antibodies, Bacterial,
pubmed-meshheading:10526194-Autoantibodies,
pubmed-meshheading:10526194-Campylobacter jejuni,
pubmed-meshheading:10526194-Child,
pubmed-meshheading:10526194-Female,
pubmed-meshheading:10526194-G(M1) Ganglioside,
pubmed-meshheading:10526194-Gangliosides,
pubmed-meshheading:10526194-Guillain-Barre Syndrome,
pubmed-meshheading:10526194-Humans,
pubmed-meshheading:10526194-Immunoglobulin G,
pubmed-meshheading:10526194-Male,
pubmed-meshheading:10526194-Middle Aged,
pubmed-meshheading:10526194-Neural Conduction,
pubmed-meshheading:10526194-Predictive Value of Tests
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pubmed:year |
1999
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pubmed:articleTitle |
Acute motor axonal neuropathy and acute motor-sensory axonal neuropathy share a common immunological profile.
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pubmed:affiliation |
Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan. yuki@dokkyomed.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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