Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1999-11-16
pubmed:abstractText
Cardiotrophin-1 (CT-1), an IL-6-related cytokine, causes hypertrophy of cardiac myocytes and has pleiotropic effects on various other cell types, including motoneurons. Here, we analyzed systemic CT-1 effects in progressive motor neuronopathy (pmn) mice that suffer from progressive motoneuronal degeneration, muscle paralysis, and premature death. Administration of an adenoviral CT-1 vector to newborn pmn mice leads to sustained CT-1 expression in the injected muscles and bloodstream, prolonged survival of animals, and improved motor functions. CT-1-treated pmn mice showed a significantly reduced degeneration of facial motoneuron cytons and phrenic nerve myelinated axons. The terminal innervation of skeletal muscle, grossly disturbed in untreated pmn mice, was almost completely preserved in CT-1-treated pmn mice. The remarkable neuroprotection conferred by CT-1 might become clinically relevant if CT-1 side effects, including cardiotoxicity, could be circumvented by a more targeted delivery of this cytokine to the nervous system.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-10072043, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-1281520, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-1465147, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-1494954, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-1641039, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-1644927, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-2022963, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-2342575, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-3958254, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-4163073, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-6173010, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-7520198, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-7536617, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-7556664, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-7582105, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-7738033, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-7770776, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-7862649, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-7973664, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8053649, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8066451, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8201002, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8215023, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8282079, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8530062, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8601813, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8621626, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8624719, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8625793, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8640454, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8755479, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8787235, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8849607, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8875253, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-8909453, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9030543, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9037067, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9050750, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9095177, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9160251, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9212104, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9254662, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9263535, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9278535, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9437033, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9454853, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9735373, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9743571, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9749728, http://linkedlifedata.com/resource/pubmed/commentcorrection/10525046-9851658
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1077-85
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Adenoviral cardiotrophin-1 gene transfer protects pmn mice from progressive motor neuronopathy.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale (INSERM) U.129, Institut Cochin de Génétique Moléculaire, 75014 Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't