Linked Life Data

10523748

Source:http://linkedlifedata.com/resource/pubmed/id/10523748

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1999-12-28
pubmed:abstractText
Different methods for estimating the effect of treatment actually received in a longitudinal placebo-controlled trial with non-compliance are discussed. Total mortality from the ATBC Study is used as an illustrative example. In the ATBC Study some 25 per cent of the participants dropped out from active follow-up prior to the scheduled end of the study. The 'intention-to-treat' analysis showed an increased death risk in the beta-carotene arm when compared with the no beta-carotene arm. Owing to considerable non-compliance it is also of interest to estimate the effect of beta-carotene actually received. We use a simple model for the treatment action and discuss three methods for estimation of the treatment effect under the model - the 'intention-to-treat' approach, the 'as-treated' approach and the g-estimation approach. These approaches are compared in a simulation study under different settings for non-compliance. Finally, the data from the ATBC Study are analysed using the proposed methods.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0277-6715
pubmed:author
pubmed:copyrightInfo
Copyright 1999 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2879-97
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Correcting for non-compliance in randomized trials: an application to the ATBC Study.
pubmed:affiliation
Rolf Nevanlinna Institute, P.O. Box 4, FIN-00014, Helsinki, Finland. Pasi.Korhonen@RNI.Helsinki.fi
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't