Source:http://linkedlifedata.com/resource/pubmed/id/10523008
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1999-11-4
|
| pubmed:abstractText |
This is a pilot dose-finding study of spermatogenic suppression using testosterone undecanoate (TU) injections alone in normal Chinese men. Thirty-two healthy men were recruited. Volunteers underwent pretreatment evaluation, then a treatment period in which group I (n = 13) received 500 mg TU, group II (n = 12) received 1000 mg TU, and group III (n = 7) received placebo, respectively, at monthly intervals during the treatment period (or until azoospermia was achieved). Thereafter, they underwent a recovery period until all parameters returned to pretreatment levels. Eleven of 12 volunteers in the 500-mg TU group, and all volunteers in the 1000-mg TU group became azoospermic. Faster suppression of spermatogenesis was achieved in the 1000-mg TU group. Serum testosterone increased significantly in the higher dose group at weeks 8 and 12, but remained within the normal range. Mean serum LH and FSH were profoundly suppressed by both doses to undetectable levels at week 16. TU injections did not cause a significant change in high density lipoprotein cholesterol levels. No serious side-effects were found. We conclude that both dosages of TU can effectively, safely, and reversibly suppress spermatogenesis in normal Chinese men.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptive Agents, Male,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadal Steroid Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/testosterone undecanoate
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0021-972X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
84
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3642-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10523008-Adult,
pubmed-meshheading:10523008-Asian Continental Ancestry Group,
pubmed-meshheading:10523008-Body Weight,
pubmed-meshheading:10523008-Contraceptive Agents, Male,
pubmed-meshheading:10523008-Dose-Response Relationship, Drug,
pubmed-meshheading:10523008-Double-Blind Method,
pubmed-meshheading:10523008-Gonadal Steroid Hormones,
pubmed-meshheading:10523008-Hemoglobins,
pubmed-meshheading:10523008-Humans,
pubmed-meshheading:10523008-Injections,
pubmed-meshheading:10523008-Lipids,
pubmed-meshheading:10523008-Male,
pubmed-meshheading:10523008-Middle Aged,
pubmed-meshheading:10523008-Organ Size,
pubmed-meshheading:10523008-Pilot Projects,
pubmed-meshheading:10523008-Reference Values,
pubmed-meshheading:10523008-Sperm Count,
pubmed-meshheading:10523008-Testis,
pubmed-meshheading:10523008-Testosterone
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| pubmed:year |
1999
|
| pubmed:articleTitle |
A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men.
|
| pubmed:affiliation |
Department of Endocrinology, National Research Institute for Family Planning, Beijing, China.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|