Linked Life Data

10522893

Source:http://linkedlifedata.com/resource/pubmed/id/10522893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-12-17
pubmed:abstractText
Huntington's disease (HD) is attributed to a triplet CAG repeat mutation, and about half of the variation in onset age can be explained by the size of the repeat expansion. Recently, a TAA repeat polymorphism in close linkage to the kainate receptor, GluR6, was reported related to onset age in HD. We examined this polymorphism in 258 unrelated HD-affected persons (172 from a clinic sample and 86 from a postmortem series). This study confirms that the 155 allele is associated with younger onset age of HD and suggests that it is in linkage disequilibrium with a variant of the GluR6 gene or another gene in this region.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-3878
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1330-2
pubmed:dateRevised
2010-1-13
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Evidence for the GluR6 gene associated with younger onset age of Huntington's disease.
pubmed:affiliation
Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.