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pubmed-article:10522712pubmed:abstractTextNovel sulfonamide matrix metalloproteinase inhibitors of general formula (9) were synthesised by a route involving a stereoselective conjugate addition reaction. Enzyme selectivity was found to be dependant on the nature of the sulfonamide substituents. Compounds (9f, 9q) are potent selective collagenase inhibitors with good oral bioavailability.lld:pubmed
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pubmed-article:10522712pubmed:articleTitleThe synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors.lld:pubmed
pubmed-article:10522712pubmed:affiliationBritish Biotech Pharmaceuticals Limited, Cowley, Oxford. martinf@britbio.co.uklld:pubmed
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