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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1999-12-17
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pubmed:abstractText |
Novel sulfonamide matrix metalloproteinase inhibitors of general formula (9) were synthesised by a route involving a stereoselective conjugate addition reaction. Enzyme selectivity was found to be dependant on the nature of the sulfonamide substituents. Compounds (9f, 9q) are potent selective collagenase inhibitors with good oral bioavailability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BeckettR PRP,
pubmed-author:BellamyC LCL,
pubmed-author:CourtneyP FPF,
pubmed-author:DaviesS JSJ,
pubmed-author:DoddRR,
pubmed-author:DrummondA HAH,
pubmed-author:MartinF MFM,
pubmed-author:PatelS RSR,
pubmed-author:PrattL MLM,
pubmed-author:RickettsM LML,
pubmed-author:ToddR SRS,
pubmed-author:TuffnellA RAR,
pubmed-author:WardJ WJW,
pubmed-author:WhittakerMM
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2887-92
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10522712-Administration, Oral,
pubmed-meshheading:10522712-Animals,
pubmed-meshheading:10522712-Antineoplastic Agents,
pubmed-meshheading:10522712-Biological Availability,
pubmed-meshheading:10522712-Hydrogen Bonding,
pubmed-meshheading:10522712-Hydroxamic Acids,
pubmed-meshheading:10522712-Matrix Metalloproteinases,
pubmed-meshheading:10522712-Molecular Structure,
pubmed-meshheading:10522712-Protease Inhibitors,
pubmed-meshheading:10522712-Rats,
pubmed-meshheading:10522712-Sulfonamides
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pubmed:year |
1999
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pubmed:articleTitle |
The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors.
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pubmed:affiliation |
British Biotech Pharmaceuticals Limited, Cowley, Oxford. martinf@britbio.co.uk
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pubmed:publicationType |
Journal Article
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