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pubmed-article:10522181pubmed:abstractTextThe objective of this study was to evaluate the effect of bone morphogenetic protein (BMP) on the bond strength of titanium (Ti) implants at the bone-implant interface. Thirty-six Brånemark screw implants (3.75 mm diameter by 15 mm long) were implanted for 3 and 12 weeks. At 3 weeks after implantation, the mean reverse torque value for implants stimulated with BMP delivered using an atelopeptide type-I collagen carrier (74.2 +/- 5.2 N cm) was observed to be statistically greater (P < 0.000016) than the mean reverse torque value for control Ti implants (32.8 +/- 1.1 N cm). Similarly, at 12 weeks after implantation, the mean reverse torque value for implants stimulated with BMP (89.2 +/- 2.7 N cm) was statistically greater (P < 0.0042) than the mean reverse torque value for control Ti implants (75.8 +/- 2.4 N cm). In addition, histomorphometric evaluations indicated more bone contact with the BMP stimulated implant surfaces compared to the controls after 3 weeks implantation. It was concluded from this study that the use of BMP-atelopeptide type-I collagen mixture is an effective means of obtaining greater bond strength at the bone implant interface within a shorter time period than Ti implants without BMP.lld:pubmed
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pubmed-article:10522181pubmed:authorpubmed-author:ChenH YHYlld:pubmed
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pubmed-article:10522181pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10522181pubmed:articleTitleBMP stimulation of bone response adjacent to titanium implants in vivo.lld:pubmed
pubmed-article:10522181pubmed:affiliationDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, Japan.lld:pubmed
pubmed-article:10522181pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10522181pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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