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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1999-12-16
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pubmed:abstractText |
mRNA encoding the T-box transcription factor VegT is located throughout the vegetal pole of the Xenopus egg and is believed to play an important part in endoderm and mesoderm formation. We find that VegT generates endoderm both by cell-autonomous action and by generating TGF-beta family signals, the latter being entirely responsible for its mesoderm-inducing activity. Signalling molecules induced cell-autonomously by VegT include derrière, Xnr4 and activin B. Xnr1 and Xnr2 are also induced, but primarily in a non-autonomous manner. All of these signalling molecules are found in the blastula and gastrula vegetal pole and induce both endoderm and mesoderm in the animal cap assay, and hence are good candidates both for the endogenous zygotic mesoderm-inducing signal and for reinforcing the vegetal expression of endoderm markers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Activins,
http://linkedlifedata.com/resource/pubmed/chemical/Brachyury protein,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fetal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ndr2 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Ndr2 protein, vertebrate,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SOXF Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/VegT protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/XNR4 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xnr1 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/activin B,
http://linkedlifedata.com/resource/pubmed/chemical/derriere protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/myelopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/sox17a protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/sox17b.1 protein, Xenopus
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4903-11
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:10518506-Activins,
pubmed-meshheading:10518506-Animals,
pubmed-meshheading:10518506-DNA-Binding Proteins,
pubmed-meshheading:10518506-Embryo, Nonmammalian,
pubmed-meshheading:10518506-Embryonic Induction,
pubmed-meshheading:10518506-Endoderm,
pubmed-meshheading:10518506-Fetal Proteins,
pubmed-meshheading:10518506-Gene Expression Regulation, Developmental,
pubmed-meshheading:10518506-Growth Substances,
pubmed-meshheading:10518506-High Mobility Group Proteins,
pubmed-meshheading:10518506-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:10518506-Mesoderm,
pubmed-meshheading:10518506-Oligopeptides,
pubmed-meshheading:10518506-Peptides,
pubmed-meshheading:10518506-Proteins,
pubmed-meshheading:10518506-SOXF Transcription Factors,
pubmed-meshheading:10518506-Signal Transduction,
pubmed-meshheading:10518506-T-Box Domain Proteins,
pubmed-meshheading:10518506-Transcription Factors,
pubmed-meshheading:10518506-Transforming Growth Factor beta,
pubmed-meshheading:10518506-Xenopus,
pubmed-meshheading:10518506-Xenopus Proteins,
pubmed-meshheading:10518506-Zygote
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pubmed:year |
1999
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pubmed:articleTitle |
Mode of action of VegT in mesoderm and endoderm formation.
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pubmed:affiliation |
Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK. hw@dna.bio.warwick.ac.uk.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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