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rdf:type |
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lifeskim:mentions |
umls-concept:C0007570,
umls-concept:C0012655,
umls-concept:C0022885,
umls-concept:C0023745,
umls-concept:C0032863,
umls-concept:C0039593,
umls-concept:C0205345,
umls-concept:C0208973,
umls-concept:C0281825,
umls-concept:C0679199,
umls-concept:C0919453,
umls-concept:C1517892,
umls-concept:C1521797,
umls-concept:C1704666
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pubmed:issue |
5
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pubmed:dateCreated |
1999-12-7
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pubmed:abstractText |
Susceptibility to coeliac disease is genetically determined by possession of specific HLA DQ alleles, acting in concert with one or more non-HLA linked genes. The pattern of familial risk is most parsimonious with a multiplicative model for the interaction between these two classes of genes. Haplotype sharing probabilities across the HLA region in affected sibling pairs suggest that genes within the MHC complex contribute no more than 40% of the sibling familial risk of coeliac disease, making the non-HLA linked gene (or genes) the stronger determinant of coeliac disease susceptibility. Attempts to localise these non-HLA linked genes have been carried out using both linkage and association tests.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-1727768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-2060769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-2301393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-2744033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-307512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-3201123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-3484455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-4694691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-6401509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-6951410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-7581446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-7670254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-8359659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-8783752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-8783753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-8801636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-8896565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-8900224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-8944229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-9064791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-9259281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-9365784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-9399906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-9497251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10517901-9648988
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
668-71
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10517901-Alleles,
pubmed-meshheading:10517901-Celiac Disease,
pubmed-meshheading:10517901-Genes, MHC Class I,
pubmed-meshheading:10517901-Genetic Linkage,
pubmed-meshheading:10517901-Genetic Markers,
pubmed-meshheading:10517901-Genetic Predisposition to Disease,
pubmed-meshheading:10517901-Heterozygote,
pubmed-meshheading:10517901-Humans,
pubmed-meshheading:10517901-Linkage Disequilibrium,
pubmed-meshheading:10517901-Risk,
pubmed-meshheading:10517901-Sample Size
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pubmed:year |
1999
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pubmed:articleTitle |
Relative power of linkage and transmission disequilibrium test strategies to detect non-HLA linked coeliac disease susceptibility genes.
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pubmed:affiliation |
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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