A recent meta-analysis found calcium supplementation to be highly effective in preventing preeclampsia but a large National Institutes of Health trial (Calcium for Preeclampsia Prevention [CPEP]) found no risk reduction due to calcium in healthy nulliparous women.
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Development, Bethesda, MD 20892-7510, USA. DerSimonian@nih.gov