Source:http://linkedlifedata.com/resource/pubmed/id/10515807
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-12-9
|
| pubmed:abstractText |
The pathogenesis of human T-cell lymphotropic virus type I (HTLV-I) in adult T-cell leukemia/lymphoma (ATL) and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is poorly understood. We prospectively followed up and evaluated the virologic correlates of infection in transfusion recipients after seroconversion, in asymptomatic carriers, and in ATL and HAM/TSP patients. Proviral DNA levels (copies/105 lymphocytes) were determined by real-time automated polymerase chain reaction and antibody titers by end-point dilution by use of an HTLV-I enzyme-linked immunoassay. In early infection, proviral load was initially elevated (median, 212 copies/105 lymphocytes at time 1) and later decreased (median, 99 copies at time 2, and 27 copies at time 3). Corresponding antibody titers were low at time 1 (1:2154), had significantly increased by time 2 (1:12312), and were stable by time 3 (1:4694). These viral markers were significantly lower in asymptomatic carriers than in HAM/TSP or ATL patients. Therefore, proviral load and antibody titers may be useful as predictive markers of disease among carriers.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
180
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1487-93
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10515807-Adolescent,
pubmed-meshheading:10515807-Adult,
pubmed-meshheading:10515807-Aged,
pubmed-meshheading:10515807-Blood Transfusion,
pubmed-meshheading:10515807-Carrier State,
pubmed-meshheading:10515807-DNA, Viral,
pubmed-meshheading:10515807-Disease Progression,
pubmed-meshheading:10515807-Female,
pubmed-meshheading:10515807-HTLV-I Antibodies,
pubmed-meshheading:10515807-HTLV-I Infections,
pubmed-meshheading:10515807-Human T-lymphotropic virus 1,
pubmed-meshheading:10515807-Humans,
pubmed-meshheading:10515807-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:10515807-Male,
pubmed-meshheading:10515807-Middle Aged,
pubmed-meshheading:10515807-Paraparesis, Tropical Spastic,
pubmed-meshheading:10515807-Pregnancy,
pubmed-meshheading:10515807-Pregnancy Complications, Infectious,
pubmed-meshheading:10515807-Prospective Studies,
pubmed-meshheading:10515807-Proviruses,
pubmed-meshheading:10515807-Viral Load
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Quantitative proviral DNA and antibody levels in the natural history of HTLV-I infection.
|
| pubmed:affiliation |
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA. mannsa@epndce.nci.nih.gov
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|