|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0020861,
umls-concept:C0021017,
umls-concept:C0035015,
umls-concept:C0205369,
umls-concept:C0205421,
umls-concept:C0301625,
umls-concept:C0333668,
umls-concept:C0522537,
umls-concept:C1548437,
umls-concept:C1882923
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1999-11-5
|
|
pubmed:abstractText |
Hamster hearts transplanted into untreated rats undergo delayed xenograft rejection (DXR). This acute inflammatory response is associated with the deposition of anti-graft antibodies of the immunoglobulin (Ig)M isotype in the vasculature. We have previously shown that these antibodies are generated in a T cell-independent manner. In this study, we tested whether the generation of anti-graft IgM antibodies is involved in the pathogenesis of DXR. In addition, we tested whether the suppression of this antibody response would overcome DXR.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0041-1337
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
27
|
|
pubmed:volume |
68
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
844-54
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10515386-Animals,
pubmed-meshheading:10515386-Antibodies, Anti-Idiotypic,
pubmed-meshheading:10515386-Antibodies, Monoclonal,
pubmed-meshheading:10515386-B-Lymphocytes,
pubmed-meshheading:10515386-Cricetinae,
pubmed-meshheading:10515386-Cyclosporine,
pubmed-meshheading:10515386-Graft Rejection,
pubmed-meshheading:10515386-Graft Survival,
pubmed-meshheading:10515386-Heart Transplantation,
pubmed-meshheading:10515386-Immunoglobulin Isotypes,
pubmed-meshheading:10515386-Immunoglobulin M,
pubmed-meshheading:10515386-Immunosuppressive Agents,
pubmed-meshheading:10515386-Killer Cells, Natural,
pubmed-meshheading:10515386-Macrophages,
pubmed-meshheading:10515386-Male,
pubmed-meshheading:10515386-Mesocricetus,
pubmed-meshheading:10515386-Rats,
pubmed-meshheading:10515386-Rats, Inbred Lew,
pubmed-meshheading:10515386-T-Lymphocytes,
pubmed-meshheading:10515386-Transplantation, Heterologous
|
|
pubmed:year |
1999
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|
pubmed:articleTitle |
Suppression of delayed xenograft rejection by specific depletion of elicited antibodies of the IgM isotype.
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|
pubmed:affiliation |
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
