pubmed-article:10515191 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10515191 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
pubmed-article:10515191 | lifeskim:mentions | umls-concept:C0017462 | lld:lifeskim |
pubmed-article:10515191 | lifeskim:mentions | umls-concept:C0917798 | lld:lifeskim |
pubmed-article:10515191 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
pubmed-article:10515191 | lifeskim:mentions | umls-concept:C0206529 | lld:lifeskim |
pubmed-article:10515191 | lifeskim:mentions | umls-concept:C0205234 | lld:lifeskim |
pubmed-article:10515191 | lifeskim:mentions | umls-concept:C2348867 | lld:lifeskim |
pubmed-article:10515191 | lifeskim:mentions | umls-concept:C0765373 | lld:lifeskim |
pubmed-article:10515191 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:10515191 | pubmed:dateCreated | 1999-11-16 | lld:pubmed |
pubmed-article:10515191 | pubmed:abstractText | The neuroprotective effects of a selective Group II metabotropic glutamate receptor (mGluR) agonist, LY379268, have been evaluated against global and focal cerebral ischaemia. Loss of CA1 hippocampal neurones following 5 min bilateral occlusion of the carotid artery (BCAO) in the gerbil was almost completely prevented by LY379268 (10 mg/kg, i.p.) given 30 min post-occlusion (P < 0.001); 10 mg/kg 1 h after and 20 mg/kg 2 h after BCAO also produced significant neuroprotection (P < 0.05). Similarly the BCAO-induced increase in TUNEL positive cells at 5 days post-occlusion was reduced by LY379268. By contrast the size of the infarct following middle cerebral artery occlusion (MCAO) induced by endothelin-1 infusion in the rat was unaffected by either 10 or 20 mg/kg i.p. of LY379268. This contrast between the results from these two animal models with LY379268, agrees with previous data on a less potent but similarly selective mGluR2/3 agonist, LY354740. It further suggests that mGluR Group II agonists are likely to have more utility in global, than in focal, cerebral ischaemia. | lld:pubmed |
pubmed-article:10515191 | pubmed:language | eng | lld:pubmed |
pubmed-article:10515191 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10515191 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:10515191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:10515191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10515191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10515191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10515191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10515191 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10515191 | pubmed:month | Oct | lld:pubmed |
pubmed-article:10515191 | pubmed:issn | 0304-3940 | lld:pubmed |
pubmed-article:10515191 | pubmed:author | pubmed-author:LodgeDD | lld:pubmed |
pubmed-article:10515191 | pubmed:author | pubmed-author:O'NeillM JMJ | lld:pubmed |
pubmed-article:10515191 | pubmed:author | pubmed-author:BonoLL | lld:pubmed |
pubmed-article:10515191 | pubmed:author | pubmed-author:WardM AMA | lld:pubmed |
pubmed-article:10515191 | pubmed:author | pubmed-author:MonnJ AJA | lld:pubmed |
pubmed-article:10515191 | pubmed:author | pubmed-author:HicksC ACA | lld:pubmed |
pubmed-article:10515191 | pubmed:author | pubmed-author:RagumoorthyNN | lld:pubmed |
pubmed-article:10515191 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10515191 | pubmed:day | 8 | lld:pubmed |
pubmed-article:10515191 | pubmed:volume | 273 | lld:pubmed |
pubmed-article:10515191 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10515191 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10515191 | pubmed:pagination | 191-4 | lld:pubmed |
pubmed-article:10515191 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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pubmed-article:10515191 | pubmed:meshHeading | pubmed-meshheading:10515191... | lld:pubmed |
pubmed-article:10515191 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10515191 | pubmed:articleTitle | LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. | lld:pubmed |
pubmed-article:10515191 | pubmed:affiliation | Eli Lilly & Co., Ltd., Lilly Research Centre, Erl Wood Manor, Surrey, UK. | lld:pubmed |
pubmed-article:10515191 | pubmed:publicationType | Journal Article | lld:pubmed |
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