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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-11-16
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pubmed:abstractText |
The neuroprotective effects of a selective Group II metabotropic glutamate receptor (mGluR) agonist, LY379268, have been evaluated against global and focal cerebral ischaemia. Loss of CA1 hippocampal neurones following 5 min bilateral occlusion of the carotid artery (BCAO) in the gerbil was almost completely prevented by LY379268 (10 mg/kg, i.p.) given 30 min post-occlusion (P < 0.001); 10 mg/kg 1 h after and 20 mg/kg 2 h after BCAO also produced significant neuroprotection (P < 0.05). Similarly the BCAO-induced increase in TUNEL positive cells at 5 days post-occlusion was reduced by LY379268. By contrast the size of the infarct following middle cerebral artery occlusion (MCAO) induced by endothelin-1 infusion in the rat was unaffected by either 10 or 20 mg/kg i.p. of LY379268. This contrast between the results from these two animal models with LY379268, agrees with previous data on a less potent but similarly selective mGluR2/3 agonist, LY354740. It further suggests that mGluR Group II agonists are likely to have more utility in global, than in focal, cerebral ischaemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-4
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10515191-Amino Acids,
pubmed-meshheading:10515191-Animals,
pubmed-meshheading:10515191-Bicyclo Compounds,
pubmed-meshheading:10515191-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:10515191-Brain Ischemia,
pubmed-meshheading:10515191-Excitatory Amino Acid Agonists,
pubmed-meshheading:10515191-Gerbillinae,
pubmed-meshheading:10515191-Hippocampus,
pubmed-meshheading:10515191-Infarction, Middle Cerebral Artery,
pubmed-meshheading:10515191-Male,
pubmed-meshheading:10515191-Neuroprotective Agents,
pubmed-meshheading:10515191-Rats,
pubmed-meshheading:10515191-Rats, Sprague-Dawley,
pubmed-meshheading:10515191-Receptors, Metabotropic Glutamate,
pubmed-meshheading:10515191-Stereoisomerism
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pubmed:year |
1999
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pubmed:articleTitle |
LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia.
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pubmed:affiliation |
Eli Lilly & Co., Ltd., Lilly Research Centre, Erl Wood Manor, Surrey, UK.
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pubmed:publicationType |
Journal Article
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