Linked Life Data

10514488

Source:http://linkedlifedata.com/resource/pubmed/id/10514488

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
42
pubmed:dateCreated
1999-11-19
pubmed:abstractText
Hepatic steatosis is common in non-insulin-dependent diabetes and can be associated with fibrosis and cirrhosis in a subset of individuals. Increased rates of fatty acid synthesis have been reported in livers from rodent models of diabetes and may contribute to the development of steatosis. Sterol regulatory element-binding proteins (SREBPs) are a family of regulated transcription factors that stimulate lipid synthesis in liver. In the current studies, we measured the content of SREBPs in livers from two mouse models of diabetes, obese ob/ob mice and transgenic aP2-SREBP-1c436 (aP2-SREBP-1c) mice that overexpress nuclear SREBP-1c only in adipose tissue. The aP2-SREBP-1c mice exhibit a syndrome that resembles congenital generalized lipodystrophy in humans. Both lines of mice develop hyperinsulinemia, hyperglycemia, and hepatic steatosis. Nuclear SREBP-1c protein levels were significantly elevated in livers from ob/ob and aP2-SREBP-1c mice compared with wild-type mice. Increased nuclear SREBP-1c protein was associated with elevated mRNA levels for known SREBP target genes involved in fatty acid biosynthesis, which led to significantly higher rates of hepatic fatty acid synthesis in vivo. These studies suggest that increased levels of nuclear SREBP-1c contribute to the elevated rates of hepatic fatty acid synthesis that leads to steatosis in diabetic mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
274
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
30028-32
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10514488-Animals, pubmed-meshheading:10514488-Blotting, Western, pubmed-meshheading:10514488-CCAAT-Enhancer-Binding Proteins, pubmed-meshheading:10514488-Cell Nucleus, pubmed-meshheading:10514488-DNA-Binding Proteins, pubmed-meshheading:10514488-Diabetes Mellitus, Type 2, pubmed-meshheading:10514488-Disease Models, Animal, pubmed-meshheading:10514488-Fatty Liver, pubmed-meshheading:10514488-Gene Expression Regulation, pubmed-meshheading:10514488-Isoenzymes, pubmed-meshheading:10514488-Lipids, pubmed-meshheading:10514488-Liver, pubmed-meshheading:10514488-Mice, pubmed-meshheading:10514488-Mice, Inbred C57BL, pubmed-meshheading:10514488-Nuclear Proteins, pubmed-meshheading:10514488-Stearoyl-CoA Desaturase, pubmed-meshheading:10514488-Sterol Regulatory Element Binding Protein 1, pubmed-meshheading:10514488-Transcription Factors
pubmed:year
1999
pubmed:articleTitle
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus.
pubmed:affiliation
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9046, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't