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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-11-4
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pubmed:abstractText |
Most colorectal cancers have loss of function mutations in the adenomatosis polyposis coli (APC) tumor suppressor gene. This leads to accumulation of beta-catenin, which together with the DNA binding protein TCF-4 functions as a transcriptional activator. Recently defined target genes are c-myc and cyclin D1, linking the APC gene defect to the capacity for autonomous proliferation of colon tumors. Here we report the identification of the matrix metalloproteinase MMP-7 as another target gene of beta-catenin/TCF-4. MMP-7 is overexpressed in 80% of human colorectal cancers and known to be an important factor for early tumor growth, with a potential function also for later progression steps, like invasion and metastasis. Our results explain the high percentage of MMP-7 overexpression in colon tumors. Moreover they indicate that defects in the APC tumor suppressor gene may also have an influence on later steps of colon tumor progression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-10201372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-10362259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-2438556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-3545431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-7705951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-7889484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8062282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8068180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8294454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8417833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8514452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8531010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8597958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8754851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8756721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8808707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8861899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-8913260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9037065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9038212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9065401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9065402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9108461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9290698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9293916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9506519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9679977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9727977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9820866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10514384-9990071
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TCF Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/TCF7L2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor 7-Like 2...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1033-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10514384-Cell Nucleus,
pubmed-meshheading:10514384-Colorectal Neoplasms,
pubmed-meshheading:10514384-Cytoskeletal Proteins,
pubmed-meshheading:10514384-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10514384-Genes, APC,
pubmed-meshheading:10514384-Genes, Dominant,
pubmed-meshheading:10514384-Glutathione Transferase,
pubmed-meshheading:10514384-HT29 Cells,
pubmed-meshheading:10514384-HeLa Cells,
pubmed-meshheading:10514384-Humans,
pubmed-meshheading:10514384-Immunohistochemistry,
pubmed-meshheading:10514384-Matrix Metalloproteinase 7,
pubmed-meshheading:10514384-Promoter Regions, Genetic,
pubmed-meshheading:10514384-Recombinant Fusion Proteins,
pubmed-meshheading:10514384-TCF Transcription Factors,
pubmed-meshheading:10514384-Trans-Activators,
pubmed-meshheading:10514384-Transcription Factor 7-Like 2 Protein,
pubmed-meshheading:10514384-Transcription Factors,
pubmed-meshheading:10514384-Tumor Markers, Biological,
pubmed-meshheading:10514384-beta Catenin
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pubmed:year |
1999
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pubmed:articleTitle |
beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer.
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pubmed:affiliation |
Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany. thomas.brabletz@patho.med.uni-erlangen.de
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pubmed:publicationType |
Journal Article
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