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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0014644,
umls-concept:C0233577,
umls-concept:C0871261,
umls-concept:C1334346,
umls-concept:C1427812,
umls-concept:C1539081,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1710082,
umls-concept:C2911692
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pubmed:issue |
5438
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pubmed:dateCreated |
1999-10-26
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pubmed:abstractText |
The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
300-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10514374-Animals,
pubmed-meshheading:10514374-Antibody Affinity,
pubmed-meshheading:10514374-Antigens, CD40,
pubmed-meshheading:10514374-B-Lymphocytes,
pubmed-meshheading:10514374-Cell Differentiation,
pubmed-meshheading:10514374-Female,
pubmed-meshheading:10514374-Germinal Center,
pubmed-meshheading:10514374-Herpesvirus 4, Human,
pubmed-meshheading:10514374-Immunization,
pubmed-meshheading:10514374-Immunoglobulin Class Switching,
pubmed-meshheading:10514374-Immunoglobulins,
pubmed-meshheading:10514374-Interleukin-4,
pubmed-meshheading:10514374-Lymphocyte Activation,
pubmed-meshheading:10514374-Male,
pubmed-meshheading:10514374-Mice,
pubmed-meshheading:10514374-Mice, Inbred C57BL,
pubmed-meshheading:10514374-Mice, Transgenic,
pubmed-meshheading:10514374-Molecular Mimicry,
pubmed-meshheading:10514374-NF-kappa B,
pubmed-meshheading:10514374-Signal Transduction,
pubmed-meshheading:10514374-Spleen,
pubmed-meshheading:10514374-Viral Matrix Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses.
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pubmed:affiliation |
Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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