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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-10-26
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pubmed:abstractText |
Cellular interactions are critical for the regulation of hematopoiesis. The sialomucin PSGL-1/CD162 mediates the attachment of mature leukocytes to P-selectin. We now show that PSGL-1 also functions as the sole receptor for P-selectin on primitive human CD34+ hematopoietic progenitor cells (HPC). More importantly, ligation of PSGL-1 by immobilized or soluble ligand or anti-PSGL-1 antibody results in a profound suppression of HPC proliferation stimulated by potent combinations of early acting hematopoietic growth factors. These data demonstrate an unanticipated but extremely marked growth-inhibitory effect of P-selectin on hematopoiesis and provide direct evidence that PSGL-1, in addition to its well-documented role as an adhesion molecule on mature leukocytes, is a potent negative regulator of human hematopoietic progenitors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NAD Nucleosidase,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/P-selectin ligand protein,
http://linkedlifedata.com/resource/pubmed/chemical/Stem Cell Factor
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
369-78
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10514015-ADP-ribosyl Cyclase,
pubmed-meshheading:10514015-Animals,
pubmed-meshheading:10514015-Antigens, CD,
pubmed-meshheading:10514015-Antigens, CD34,
pubmed-meshheading:10514015-Antigens, CD38,
pubmed-meshheading:10514015-Antigens, Differentiation,
pubmed-meshheading:10514015-Apoptosis,
pubmed-meshheading:10514015-Bone Marrow Cells,
pubmed-meshheading:10514015-CHO Cells,
pubmed-meshheading:10514015-Cell Adhesion,
pubmed-meshheading:10514015-Cell Division,
pubmed-meshheading:10514015-Cells, Cultured,
pubmed-meshheading:10514015-Cricetinae,
pubmed-meshheading:10514015-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:10514015-Hematopoiesis,
pubmed-meshheading:10514015-Hematopoietic Stem Cells,
pubmed-meshheading:10514015-Humans,
pubmed-meshheading:10514015-Interleukin-3,
pubmed-meshheading:10514015-Interleukin-6,
pubmed-meshheading:10514015-Ligands,
pubmed-meshheading:10514015-Membrane Glycoproteins,
pubmed-meshheading:10514015-NAD+ Nucleosidase,
pubmed-meshheading:10514015-P-Selectin,
pubmed-meshheading:10514015-Solubility,
pubmed-meshheading:10514015-Stem Cell Factor
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pubmed:year |
1999
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pubmed:articleTitle |
PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis.
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pubmed:affiliation |
Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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