Source:http://linkedlifedata.com/resource/pubmed/id/10511119
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1999-11-2
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pubmed:abstractText |
Using a dual stable isotope technique, the effect of growth hormone (GH) on whole body calcium (Ca) metabolism was studied in children (ages 5-14 years) with type III (n = 9) and IV (n = 8) osteogenesis imperfecta. Each subject was studied twice: at baseline and following a GH (0.1-0.2 U/kg per day) treatment period of 1-1.5 years. Subjects were given 42Ca intravenously and 44Ca orally. The sera and urine 42Ca and 44Ca isotopic enrichments were followed over 7 days using thermal ionization mass spectrometry. The SAAM program was used to fit a three-compartment model to the tracer data. No significant differences were observed between: (1) children with type III and IV disease; or (2) baseline studies of boys and girls within each disease type. However, GH treatment significantly increased: (1) the exchangeable calcium pool (EP) in type III patients (2086 vs. 4422 mg/day, p = 0.02); and (2) the parameter associated with bone calcium accretion in type IV patients (Vo+: 973 vs. 1560 mg/day,p = 0.03) with boys responding with a significantly greater increase than girls (p = 0.008). Although not statistically significant, a trend toward an increase in Vo+ in type III patients and in EP in type IV was observed following treatment. Our observations imply that more Ca was available for bone mineralization following GH treatment in these subjects.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
8756-3282
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
501-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10511119-Adolescent,
pubmed-meshheading:10511119-Calcification, Physiologic,
pubmed-meshheading:10511119-Calcium,
pubmed-meshheading:10511119-Child,
pubmed-meshheading:10511119-Child, Preschool,
pubmed-meshheading:10511119-Female,
pubmed-meshheading:10511119-Growth Hormone,
pubmed-meshheading:10511119-Humans,
pubmed-meshheading:10511119-Male,
pubmed-meshheading:10511119-Osteogenesis Imperfecta
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pubmed:year |
1999
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pubmed:articleTitle |
Effect of growth hormone treatment on calcium kinetics in patients with osteogenesis imperfecta type III and IV.
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pubmed:affiliation |
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. nevieira@box-n.nih.gov
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pubmed:publicationType |
Journal Article
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