Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1999-11-2
pubmed:abstractText
Nitric oxide (NO) inhalation has been reported to increase the oxygen affinity of sickle cell erythrocytes. Also, proposed allosteric mechanisms for hemoglobin, based on S-nitrosation of beta-chain cysteine 93, raise the possibility of altering the pathophysiology of sickle cell disease by inhibiting polymerization or by increasing NO delivery to the tissue. We studied the effects of a 2-hour treatment, using varying concentrations of inhaled NO. Oxygen affinity, as measured by P(50), did not respond to inhaled NO, either in controls or in individuals with sickle cell disease. At baseline, the arterial and venous levels of nitrosylated hemoglobin were not significantly different, but NO inhalation led to a dose-dependent increase in mean nitrosylated hemoglobin, and at the highest dosage, a significant arterial-venous difference emerged. The levels of nitrosylated hemoglobin are too low to affect overall hemoglobin oxygen affinity, but augmented NO transport to the microvasculature seems a promising strategy for improving microvascular perfusion.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-10099145, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-10228097, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-10336440, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-10510323, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-1502182, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-2405712, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-3771547, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-6493211, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-6626765, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-7181105, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-7733655, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-8248198, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-8566883, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-8637569, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-889569, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9192784, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9197264, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9276736, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9287233, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9357905, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9367862, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9428761, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9458886, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9462528, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9570848, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9616221, http://linkedlifedata.com/resource/pubmed/commentcorrection/10510334-9919558
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
937-45
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:10510334-Administration, Inhalation, pubmed-meshheading:10510334-Adult, pubmed-meshheading:10510334-African Continental Ancestry Group, pubmed-meshheading:10510334-Anemia, Sickle Cell, pubmed-meshheading:10510334-Erythrocytes, pubmed-meshheading:10510334-European Continental Ancestry Group, pubmed-meshheading:10510334-Female, pubmed-meshheading:10510334-Hemoglobin, Sickle, pubmed-meshheading:10510334-Hemoglobin A, pubmed-meshheading:10510334-Humans, pubmed-meshheading:10510334-Kinetics, pubmed-meshheading:10510334-Male, pubmed-meshheading:10510334-Nitric Oxide, pubmed-meshheading:10510334-Oxygen, pubmed-meshheading:10510334-Oxyhemoglobins, pubmed-meshheading:10510334-Partial Pressure, pubmed-meshheading:10510334-Reference Values, pubmed-meshheading:10510334-United States
pubmed:year
1999
pubmed:articleTitle
Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity.
pubmed:affiliation
Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. mgladwin@nih.gov
pubmed:publicationType
Journal Article